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- W4366173661 abstract "Introduction: Bullous pemphigoid (BP) is a rare autoantibody-driven blistering disease. Oral corticosteroids (OCS) are often used as part of initial therapy. There is limited research directly estimating the risk of OCS-related adverse events (AEs) in BP patients. Objective: To assess the risk of select AEs during real-world OCS use in BP patients. Methods: US adults with a new diagnosis of BP in the Optum Clinformatics database were followed from diagnosis (01/01/2016 to 06/30/2022). AEs such as cardiac, endocrine, and infectious events based on the Glucocorticoid Toxicity Index were identified using ICD codes. Crude incidence rates (IR) of OCS-related AEs were reported. A frailty model was fitted to assess risk of AEs during OCS exposure as hazard ratios. OCS exposure by dose (Low: <15mg/day, Medium: 15-30mg/day, High: >30mg/day) and concomitant medication use were included as time-varying covariates; fixed covariates, such as comorbidities, were also included. Results: Of the 2,806 BP patients identified in the database, 1190 (42%) were treated with OCS at baseline. The mean age of the cohort was 77 (SD 11.0) with 47% male, with median OCS episode duration of 112 days (IQR 37-255). Crude IR of OCS-related AEs was 2.03 (95%CI: 1.91-2.15) per patient-year. Adjusted frailty models identified an increased hazard of any AE during periods of OCS exposure for all OCS dosages, Low: 1.26 (1.16-1.37), Medium: 1.18 (1.09-1.28), High: 1.25 (1.14-1.38) relative to no OCS exposure. Conclusions: OCS exposure was associated with significantly increased hazards of AEs in BP patients. Evidence-based therapies that go beyond broad immunosuppression and target the underlying disease are needed." @default.
- W4366173661 created "2023-04-19" @default.
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- W4366173661 date "2023-05-01" @default.
- W4366173661 modified "2023-09-28" @default.
- W4366173661 title "514 A retrospective observational study to assess the risk of select adverse events of special interest during oral corticosteroid use in bullous pemphigoid patients" @default.
- W4366173661 doi "https://doi.org/10.1016/j.jid.2023.03.520" @default.
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