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- W4366174017 abstract "Basal cell carcinoma (BCC) risk is mostly defined by tumor location, size, and histological subtype (HST). Location and size are evident at the time of diagnosis but establishing HST currently relies on invasive biopsy. Superficial and nodular BCCs behave more indolently, while infiltrative, micronodular, and morpheaform BCCs are aggressive and show greater subclinical extension and recurrence risk. Thus, BCC HST drives treatment decision-making. Low-risk BCCs can be effectively treated with local destructive or topical therapies, while high-risk require surgical removal. We aimed to assess whetherin vivooptically guided high-frequency ultrasound (OG-HFUS) imaging can identify BCCs with aggressive HST and thus may aid early treatment planning. We performed a clinical and a dermoscopic examination of BCCs followed by 33 MHz OG-HFUS imaging, surgical excision, and histological examination. 52 patients with BCC were enrolled, with a mean age of 72.6±10.9 years. Histology established 13 lesions as aggressive HST (infiltrative or micronodular subtype) and 39 as low-risk HST (superficial or nodular subtype). With OG-HFUS, aggressive BCC HSTs could be distinguished from low-risk HST based on their irregular shape (p<0.0001), ill-defined margins (p<0.0001), and non-homogeneous internal echoes (p=0.004) upon statistical analysis with Fisher's exact test. Using on novel scoring system based on these criteria, OG-HFUS differentiated aggressive HSTs from low-risk with higher sensitivity (84.6%) and specificity (92.3%) than macroscopic and dermoscopic evaluation (sensitivity: 31.9%, specificity: 75.5%). Based on our results, OG-HFUS can distinguish aggressive BCC subtypes from low-risk HSTs using easily identifiable morphological parameters and may support early therapeutic decision-making." @default.
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- W4366174017 date "2023-05-01" @default.
- W4366174017 modified "2023-09-28" @default.
- W4366174017 title "542 Optically guided high-frequency ultrasound can distinguish basal cell carcinomas with aggressive histological subtypes" @default.
- W4366174017 doi "https://doi.org/10.1016/j.jid.2023.03.548" @default.
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