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- W4366174139 abstract "Introduction: Inverse psoriasis (IP) is a rare variant of plaque psoriasis that involves the flexor surfaces. Therapy is based on topical and systemic treatments, including classic systemic drugs and biologic drugs, but a defined therapeutic strategy is not present. Methods: This is a retrospective study of 1053 patients with psoriasis on Il23 and Il17 inhibitor therapy analyzing population characteristics and efficacy of different biologic drugs in patients with IP at 16, 28, 52 weeks. Results: IP was more prevalent in female compared to male (p=0,002). In our population, 78.6% (66 pts) of patients with inverse psoriasis are taking an IL17 inhibitor versus 59.8% (582) in the population without fold involvement (p=0.001). Regarding mean PASI, there were no significant differences in the two groups from baseline at 52 weeks. In the population with IP, there is greater joint involvement in the group of patients treated with anti-IL17 (p=0.011) and a lower median age of onset (p=0.011) than the group treated with anti- IL 23. Patients with anti-IL23 started with a lower mean PASI and shows a slower response than patients with anti-IL17. At 52 weeks, greater efficacy of IL23 inhibitors is observed, although not yet significant. Conclusion: More females and less response to biological treatments were found in our population than in the population without fold involvement. IL17 inhibitors are faster than IL23, but in the long term, this significance is lessened. Further studies are needed." @default.
- W4366174139 created "2023-04-19" @default.
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- W4366174139 date "2023-05-01" @default.
- W4366174139 modified "2023-09-28" @default.
- W4366174139 title "593 Inverse psoriasis involvement in moderate to severe psoriatic patients: A comparison between anti IL23 and anti IL17" @default.
- W4366174139 doi "https://doi.org/10.1016/j.jid.2023.03.600" @default.
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