Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366175158> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4366175158 endingPage "S87" @default.
- W4366175158 startingPage "S87" @default.
- W4366175158 abstract "Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma that initially starts in the skin but can progress to involve blood and extracutaneous sites with significant mortality in late stages. The presence of a dominant T-cell clone in the blood of early-stage MF patients appears to be associated with a poor prognosis. However, the identity of dominant blood T-cell clones and the degree of overlap between T-cell repertoires of blood and skin in MF have not been fully interrogated. Here, we evaluated the relationship of blood and skin T-cell repertoires and their relevance to prognosis in MF. We used high-throughput sequencing to interrogate the T-cell receptor (TCR) complementarity determining region 3 sequences in blood and skin of MF patients at the Jefferson Cutaneous Lymphoma Clinic (Adaptive Biotechnologies). ImmunoSEQ Analyzer provided T-cell repertoire overlap metric (Morisita’s index) and diversity measure (Simpson’s clonality score). Time to systemic treatment (TTST) was calculated as the time from initial diagnosis to initiation of first systemic therapy. 59 MF patients with no blood involvement at diagnosis were enrolled. 29% had a dominant clone in blood; of these, 18% were identical to dominant skin clones and 82% were distinct from the dominant clones identified in skin. We found that MF patients with discordant dominant TCR clones in blood and skin had a longer TTST compared to those with identical dominant TCR clones (P =0.0009). Furthermore, patients with discordant dominant clones had a lower degree of overall T-cell repertoire overlap between blood and skin (P <0.05) and higher blood T-cell repertoire diversity scores (P<0.05) when compared to patients with identical dominant clones in blood and skin. Our data highlights the importance of establishing clonal associations between dominant T-cell clones of the skin and blood in MF. We propose that MF patients with dominant clones in blood segregate into two cohorts with distinct prognoses based on the identity of their peripheral T-cell clones." @default.
- W4366175158 created "2023-04-19" @default.
- W4366175158 creator A5003817421 @default.
- W4366175158 creator A5007671435 @default.
- W4366175158 creator A5037427028 @default.
- W4366175158 creator A5044876202 @default.
- W4366175158 date "2023-05-01" @default.
- W4366175158 modified "2023-09-28" @default.
- W4366175158 title "508 Prognostic relevance of blood T-cell clonality in mycosis fungoides" @default.
- W4366175158 doi "https://doi.org/10.1016/j.jid.2023.03.514" @default.
- W4366175158 hasPublicationYear "2023" @default.
- W4366175158 type Work @default.
- W4366175158 citedByCount "0" @default.
- W4366175158 crossrefType "journal-article" @default.
- W4366175158 hasAuthorship W4366175158A5003817421 @default.
- W4366175158 hasAuthorship W4366175158A5007671435 @default.
- W4366175158 hasAuthorship W4366175158A5037427028 @default.
- W4366175158 hasAuthorship W4366175158A5044876202 @default.
- W4366175158 hasBestOaLocation W43661751581 @default.
- W4366175158 hasConcept C104317684 @default.
- W4366175158 hasConcept C142724271 @default.
- W4366175158 hasConcept C19317047 @default.
- W4366175158 hasConcept C203014093 @default.
- W4366175158 hasConcept C2776090121 @default.
- W4366175158 hasConcept C2776780870 @default.
- W4366175158 hasConcept C2777756187 @default.
- W4366175158 hasConcept C2777891184 @default.
- W4366175158 hasConcept C2779338263 @default.
- W4366175158 hasConcept C54355233 @default.
- W4366175158 hasConcept C71924100 @default.
- W4366175158 hasConcept C81089528 @default.
- W4366175158 hasConcept C86803240 @default.
- W4366175158 hasConcept C8891405 @default.
- W4366175158 hasConceptScore W4366175158C104317684 @default.
- W4366175158 hasConceptScore W4366175158C142724271 @default.
- W4366175158 hasConceptScore W4366175158C19317047 @default.
- W4366175158 hasConceptScore W4366175158C203014093 @default.
- W4366175158 hasConceptScore W4366175158C2776090121 @default.
- W4366175158 hasConceptScore W4366175158C2776780870 @default.
- W4366175158 hasConceptScore W4366175158C2777756187 @default.
- W4366175158 hasConceptScore W4366175158C2777891184 @default.
- W4366175158 hasConceptScore W4366175158C2779338263 @default.
- W4366175158 hasConceptScore W4366175158C54355233 @default.
- W4366175158 hasConceptScore W4366175158C71924100 @default.
- W4366175158 hasConceptScore W4366175158C81089528 @default.
- W4366175158 hasConceptScore W4366175158C86803240 @default.
- W4366175158 hasConceptScore W4366175158C8891405 @default.
- W4366175158 hasIssue "5" @default.
- W4366175158 hasLocation W43661751581 @default.
- W4366175158 hasOpenAccess W4366175158 @default.
- W4366175158 hasPrimaryLocation W43661751581 @default.
- W4366175158 hasRelatedWork W1968386713 @default.
- W4366175158 hasRelatedWork W2031132168 @default.
- W4366175158 hasRelatedWork W2033626681 @default.
- W4366175158 hasRelatedWork W2038149278 @default.
- W4366175158 hasRelatedWork W2057557676 @default.
- W4366175158 hasRelatedWork W2091542963 @default.
- W4366175158 hasRelatedWork W2145148096 @default.
- W4366175158 hasRelatedWork W2323316027 @default.
- W4366175158 hasRelatedWork W2807802402 @default.
- W4366175158 hasRelatedWork W2915611428 @default.
- W4366175158 hasVolume "143" @default.
- W4366175158 isParatext "false" @default.
- W4366175158 isRetracted "false" @default.
- W4366175158 workType "article" @default.