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- W4366175422 abstract "Sleep disturbances greatly impact quality of life. We have previously shown that 80% percent of children with atopic dermatitis (AD) in our cohort suffered from sleep disturbances and 60% from sleep-related impairment. However, the broader influence of sleep issues in children with AD has not been explored. Validated patient-oriented questionnaires were completed at each visit by children >8 years old and parents (5-7 years old) in a cross-sectional observational study of 248 children with AD. AD severity was also assessed using the Eczema Area and Severity Index (EASI), SCORing AD (SCORAD), Investigator's Global Assessment (IGA), and Patient oriented Eczema Measurement (POEM). Sleep-related impairment (SRI) and sleep disturbance (SD) were measured with Patient Reported Outcome Measurement Information System (PROMIS). No higher probability of severe SD in children with allergic rhinitis or asthma was noted. In children 5-7 years, parents-reported SD correlated with age and lower family income. SRI was reflected by a higher disease activity (EASI, SCORAD, POEM) and SDin children >8 years correlatedmoderately with disease activity from patient report (POEM (rho=0.58, p<0.001); SCORAD (rho=0.46 p<0.001)) and weakly with physician-reported severity (IGA/EASI/BSA (rho=0.35 p<0.001)). In both age groups SD prevalence, and in the younger age group also SRI, correlated with itch, pain, poorer mobility and poorer global health (rho=-0.35). More SRI as well as SD was associated with depression (rho=0.35) and anxiety (rho=0.44) (all p<0.001). A strong correlation of itch and pain was seen in both age groups, and also SD correlated with itch and pain (rho=0.80, p<0.001).During the observational period disease activity and with it sleep disturbances and psychosocial problems improved. Sleep disturbance and its daytime impairment both affect the physical and psychosocial health of children with AD, highlighting the need to document sleep impacts in holistic care." @default.
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- W4366175422 date "2023-05-01" @default.
- W4366175422 modified "2023-10-03" @default.
- W4366175422 title "485 Sleep disturbance impacts physical and psychosocial health of children with atopic dermatitis" @default.
- W4366175422 doi "https://doi.org/10.1016/j.jid.2023.03.491" @default.
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