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- W4366175566 abstract "The handheld Myoton device has been useful in a broad array of skin and soft tissue disease by measuring five biomechanical parameters: stiffness, frequency, relaxation time, decrement, and creep. To understand the effect of anatomy on these clinical biomarkers, we investigated the relationship between the Myoton biomechanical parameters and both skin (epidermis and dermis) and subcutaneous tissue thickness measured by High-Frequency Ultrasound (HFUS). We measured skin biomechanics bilaterally on the volar forearm of healthy participants (n=11, age range: 19 -72) with the Myoton. We imaged each measured site with a VevoMD HFUS (48 MHz linear probe) device. Correlations were examined between the five Myoton parameters and skin and subcutaneous tissue thickness assessed from the HFUS B-mode images. Mean skin thickness at the volar forearm was 1.26 ± 0.04 mm. Mean subcutaneous thickness at the volar forearm was 4.80 ± 0.14 mm. Myoton stiffness (Spearman ρ = -0.83, p <0.001), frequency (-0.80, p <0.001), and relaxation time (0.76, p<0.001) had significant correlations with subcutaneous tissue thickness at the 22 measured forearms. By contrast, correlations were far weaker for skin thickness. Easily and objectively acquired Myoton stiffness, frequency, and relaxation time parameters provide insights into subcutaneous tissue thickness. This finding supports the use of the Myoton as an anatomically validated method to monitor responses to new therapeutic regimens for fibrosing diseases, including chronic graft-vs-host disease and scleroderma, which traditionally rely on subjective skin exams and HFUS for clinical decision-making." @default.
- W4366175566 created "2023-04-19" @default.
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- W4366175566 date "2023-05-01" @default.
- W4366175566 modified "2023-09-28" @default.
- W4366175566 title "481 Relationship between skin and subcutaneous tissue biomechanics and thickness in healthy subjects" @default.
- W4366175566 doi "https://doi.org/10.1016/j.jid.2023.03.487" @default.
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