Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366176862> ?p ?o ?g. }
- W4366176862 endingPage "18" @default.
- W4366176862 startingPage "18" @default.
- W4366176862 abstract "Immune checkpoint inhibitors (ICIs) enhance antitumoral immune mechanisms and are used to treat various types of solid tumors including those that are microsatellite instability (MSI)-high. Uterine endometrial cancer is one of the most frequent tumor types that shows MSI-high, and, consequently, opportunities to use ICIs for endometrial cancer treatment are increasing. While using ICIs, it is important to monitor and manage various immune-related adverse events (irAEs). Here, we report two cases of secondary adrenal insufficiency during treatment of endometrial cancer with pembrolizumab. Both cases showed appetite loss and general fatigue after the 6th or 12th cycle of pembrolizumab. They were admitted to our hospital because of remarkable hyponatremia. Both cases showed no adrenocorticotropic hormone (ACTH) or cortisol response to CRH loading tests. Other pituitary hormone levels were normal, and MRI revealed no sign of hypophysitis in either patient. They were diagnosed with secondary adrenal insufficiency due to isolated ACTH deficiency and recovered soon after the administration of hydrocortisone and hydration. Thus, we should be aware of irAEs with the use of ICIs. In particular, adrenocortical insufficiency is sometimes lethal without appropriate treatment. Because the clinical symptoms are fatigue, appetite loss, and nausea, patients might be misjudged to have symptoms related to cancer. Checking serum morning cortisol before ICIs use and monitoring serum sodium levels could provide clues to diagnose secondary adrenal insufficiency." @default.
- W4366176862 created "2023-04-19" @default.
- W4366176862 creator A5001095234 @default.
- W4366176862 creator A5015175152 @default.
- W4366176862 creator A5018042617 @default.
- W4366176862 creator A5023764322 @default.
- W4366176862 creator A5043321064 @default.
- W4366176862 creator A5046402245 @default.
- W4366176862 creator A5061415439 @default.
- W4366176862 creator A5066806706 @default.
- W4366176862 creator A5071426288 @default.
- W4366176862 creator A5072585417 @default.
- W4366176862 creator A5074116833 @default.
- W4366176862 creator A5074974284 @default.
- W4366176862 creator A5077634075 @default.
- W4366176862 creator A5084039755 @default.
- W4366176862 date "2023-04-17" @default.
- W4366176862 modified "2023-09-26" @default.
- W4366176862 title "Secondary Adrenal Insufficiency Due to Isolated ACTH Deficiency Induced by Pembrolizumab: A Report of Two Cases of Uterine Endometrial Cancer" @default.
- W4366176862 cites W1510442926 @default.
- W4366176862 cites W1873924279 @default.
- W4366176862 cites W2002250199 @default.
- W4366176862 cites W2121314233 @default.
- W4366176862 cites W2587709415 @default.
- W4366176862 cites W2622499649 @default.
- W4366176862 cites W2760410509 @default.
- W4366176862 cites W2808678139 @default.
- W4366176862 cites W2902570465 @default.
- W4366176862 cites W2928480340 @default.
- W4366176862 cites W2953100816 @default.
- W4366176862 cites W2953531214 @default.
- W4366176862 cites W2983284890 @default.
- W4366176862 cites W3013308334 @default.
- W4366176862 cites W3040108668 @default.
- W4366176862 cites W3083986479 @default.
- W4366176862 cites W3145657260 @default.
- W4366176862 cites W3162660475 @default.
- W4366176862 cites W3190923135 @default.
- W4366176862 cites W3192038436 @default.
- W4366176862 cites W3203777452 @default.
- W4366176862 cites W4226407945 @default.
- W4366176862 doi "https://doi.org/10.3390/reports6020018" @default.
- W4366176862 hasPublicationYear "2023" @default.
- W4366176862 type Work @default.
- W4366176862 citedByCount "0" @default.
- W4366176862 crossrefType "journal-article" @default.
- W4366176862 hasAuthorship W4366176862A5001095234 @default.
- W4366176862 hasAuthorship W4366176862A5015175152 @default.
- W4366176862 hasAuthorship W4366176862A5018042617 @default.
- W4366176862 hasAuthorship W4366176862A5023764322 @default.
- W4366176862 hasAuthorship W4366176862A5043321064 @default.
- W4366176862 hasAuthorship W4366176862A5046402245 @default.
- W4366176862 hasAuthorship W4366176862A5061415439 @default.
- W4366176862 hasAuthorship W4366176862A5066806706 @default.
- W4366176862 hasAuthorship W4366176862A5071426288 @default.
- W4366176862 hasAuthorship W4366176862A5072585417 @default.
- W4366176862 hasAuthorship W4366176862A5074116833 @default.
- W4366176862 hasAuthorship W4366176862A5074974284 @default.
- W4366176862 hasAuthorship W4366176862A5077634075 @default.
- W4366176862 hasAuthorship W4366176862A5084039755 @default.
- W4366176862 hasBestOaLocation W43661768621 @default.
- W4366176862 hasConcept C104317684 @default.
- W4366176862 hasConcept C121608353 @default.
- W4366176862 hasConcept C126322002 @default.
- W4366176862 hasConcept C134018914 @default.
- W4366176862 hasConcept C180754005 @default.
- W4366176862 hasConcept C185592680 @default.
- W4366176862 hasConcept C2776703092 @default.
- W4366176862 hasConcept C2777088508 @default.
- W4366176862 hasConcept C2777658017 @default.
- W4366176862 hasConcept C2777701055 @default.
- W4366176862 hasConcept C2778129406 @default.
- W4366176862 hasConcept C2778709874 @default.
- W4366176862 hasConcept C2778808452 @default.
- W4366176862 hasConcept C2779767149 @default.
- W4366176862 hasConcept C2780057760 @default.
- W4366176862 hasConcept C2780194577 @default.
- W4366176862 hasConcept C2780546910 @default.
- W4366176862 hasConcept C2780580376 @default.
- W4366176862 hasConcept C55493867 @default.
- W4366176862 hasConcept C61320498 @default.
- W4366176862 hasConcept C71315377 @default.
- W4366176862 hasConcept C71924100 @default.
- W4366176862 hasConcept C90924648 @default.
- W4366176862 hasConceptScore W4366176862C104317684 @default.
- W4366176862 hasConceptScore W4366176862C121608353 @default.
- W4366176862 hasConceptScore W4366176862C126322002 @default.
- W4366176862 hasConceptScore W4366176862C134018914 @default.
- W4366176862 hasConceptScore W4366176862C180754005 @default.
- W4366176862 hasConceptScore W4366176862C185592680 @default.
- W4366176862 hasConceptScore W4366176862C2776703092 @default.
- W4366176862 hasConceptScore W4366176862C2777088508 @default.
- W4366176862 hasConceptScore W4366176862C2777658017 @default.
- W4366176862 hasConceptScore W4366176862C2777701055 @default.
- W4366176862 hasConceptScore W4366176862C2778129406 @default.
- W4366176862 hasConceptScore W4366176862C2778709874 @default.
- W4366176862 hasConceptScore W4366176862C2778808452 @default.
- W4366176862 hasConceptScore W4366176862C2779767149 @default.