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- W4366178082 abstract "Purpose: To characterize the clinical profile, assess the disease burden through the clinical course, and evaluate clinical outcomes of patients with generalized pustular psoriasis (GPP) in Taiwan. Methods: The National Health Insurance Research Database, which contains Taiwan’s national claims data, was used to estimate GPP prevalence and incidence between 2017 and 2020. Multicenter electronic medical records (EMRs) from January 2008 to December 2021 were used to analyze clinical characteristics, disease burden, and treatment outcomes. The cohort enrollment date was set as the first encounter date of GPP flares during the study period. Flare episodes were identified through a chart review and severity was determined using the GPPGA scoring system and photographs recorded in the EMR. Results: About 200 GPP cases occurred in Taiwan each year; the GPP prevalence rate was 4.75 per 100,000 population in 2020. We observed 115 moderate/severe flare episodes involving 58 patients during the study period, and 50.4% were severe flares. The average number of moderate/severe flares per patient-year was 0.53. Seventeen (53.1%) of 32 patients who had received a gene survey had an IL36RN mutation. The rates of complete and partial response to conventional treatments for GPP flare were 0 and 3.5% on day 2, 0 and 19.1% in week 1, 3.5% and 35.7% in week 4, and 3.6% and 32.4% in week 12, respectively. Conclusions: GPP imposes a high burden on patients and the current treatments remain suboptimal." @default.
- W4366178082 created "2023-04-19" @default.
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- W4366178082 date "2023-05-01" @default.
- W4366178082 modified "2023-09-28" @default.
- W4366178082 title "413 Clinical characteristics and disease burden of patients with generalized pustular psoriasis in Taiwan: A study using electronic medical records & national claims databases" @default.
- W4366178082 doi "https://doi.org/10.1016/j.jid.2023.03.419" @default.
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