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- W4366179612 abstract "The Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCoV-2) resulted in millions of deaths worldwide. In adults, it can lead to serious complications such as Acute Respiratory Distress Syndrome (ARDS), renal failure, encephalitis, acute cardiac illness, thromboembolism, and multiorgan failure. However, in infants and children, it causes mild illness. The current evidence showed hyperinflammatory syndrome is the reason for most of the deaths in patients with severe COVID-19. There are increasing research activities around immunomodulatory drugs to manage SARSCoV-2 induced dysregulated immune response. However, these immunomodulatory drugs are currently approved by FDA for the prevention and treatment of certain inflammatory disorders, such as rheumatoid arthritis, gout, recurrent pericarditis, and multiple sclerosis. Here, we summarise the drugs studied in several randomised clinical trials to demonstrate the efficacy and safety in treating the uncontrolled immune response of COVID-19 patients." @default.
- W4366179612 created "2023-04-19" @default.
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- W4366179612 date "2023-01-01" @default.
- W4366179612 modified "2023-10-06" @default.
- W4366179612 title "Immunomodulators and SARS-CoV-2: Management of the Dysregulated Immune Response" @default.
- W4366179612 doi "https://doi.org/10.7860/jcdr/2023/60636.17733" @default.
- W4366179612 hasPublicationYear "2023" @default.
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