Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366179675> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4366179675 endingPage "S9" @default.
- W4366179675 startingPage "S9" @default.
- W4366179675 abstract "Background: Application of haptens to the skin induces release of immune stimulatory adenosine triphosphate into the extracellular space. This “danger” signal can be converted to immunosuppressive adenosine by the action of the ectonucleotidases CD39 and CD73, expressed by skin and immune cells. CD73 deficient mice have thicker ear swelling 1 day after challenge. On the other hand, neutrophil is also essential to induce contact hypersensitivity(CHS) in sensitization phase. Objective: To investigate the role of CD73 expression and neutrophil during 2,4,6-trinitrochlorobenzene (TNCB) induced CHS reactions. Methods: Wild type (wt) and CD73 deficient mice were subjected to TNCB induced CHS. In the different mouse strains, the resulting of ear swelling reaction was recorded. And ears of wt mice were painted with adenosine agonist. Results: In CD73 deficient mice, ear swelling 1 day after sensitization was thicker compared to wt mice and increased neutrophil infiltrated into the skin. Wt mice painted with adenosine agonist had less ear swelling and infiltrated neutrophil into the skin. Conclusion: Adenosine production in the ear is necessary to limit CHS reaction induced by neutrophil in sensitization phase." @default.
- W4366179675 created "2023-04-19" @default.
- W4366179675 creator A5021087906 @default.
- W4366179675 creator A5021450673 @default.
- W4366179675 creator A5037938106 @default.
- W4366179675 creator A5044863842 @default.
- W4366179675 creator A5072635806 @default.
- W4366179675 creator A5090670800 @default.
- W4366179675 date "2023-05-01" @default.
- W4366179675 modified "2023-09-28" @default.
- W4366179675 title "052 Adenosine production in the ear is necessary to limit contact hypersensitivity reaction induced by neutrophil" @default.
- W4366179675 doi "https://doi.org/10.1016/j.jid.2023.03.053" @default.
- W4366179675 hasPublicationYear "2023" @default.
- W4366179675 type Work @default.
- W4366179675 citedByCount "0" @default.
- W4366179675 crossrefType "journal-article" @default.
- W4366179675 hasAuthorship W4366179675A5021087906 @default.
- W4366179675 hasAuthorship W4366179675A5021450673 @default.
- W4366179675 hasAuthorship W4366179675A5037938106 @default.
- W4366179675 hasAuthorship W4366179675A5044863842 @default.
- W4366179675 hasAuthorship W4366179675A5072635806 @default.
- W4366179675 hasAuthorship W4366179675A5090670800 @default.
- W4366179675 hasBestOaLocation W43661796751 @default.
- W4366179675 hasConcept C126322002 @default.
- W4366179675 hasConcept C134018914 @default.
- W4366179675 hasConcept C147483822 @default.
- W4366179675 hasConcept C170493617 @default.
- W4366179675 hasConcept C185592680 @default.
- W4366179675 hasConcept C203014093 @default.
- W4366179675 hasConcept C2776217527 @default.
- W4366179675 hasConcept C2776991684 @default.
- W4366179675 hasConcept C2777983669 @default.
- W4366179675 hasConcept C2778938600 @default.
- W4366179675 hasConcept C29144244 @default.
- W4366179675 hasConcept C71924100 @default.
- W4366179675 hasConcept C8891405 @default.
- W4366179675 hasConcept C98274493 @default.
- W4366179675 hasConceptScore W4366179675C126322002 @default.
- W4366179675 hasConceptScore W4366179675C134018914 @default.
- W4366179675 hasConceptScore W4366179675C147483822 @default.
- W4366179675 hasConceptScore W4366179675C170493617 @default.
- W4366179675 hasConceptScore W4366179675C185592680 @default.
- W4366179675 hasConceptScore W4366179675C203014093 @default.
- W4366179675 hasConceptScore W4366179675C2776217527 @default.
- W4366179675 hasConceptScore W4366179675C2776991684 @default.
- W4366179675 hasConceptScore W4366179675C2777983669 @default.
- W4366179675 hasConceptScore W4366179675C2778938600 @default.
- W4366179675 hasConceptScore W4366179675C29144244 @default.
- W4366179675 hasConceptScore W4366179675C71924100 @default.
- W4366179675 hasConceptScore W4366179675C8891405 @default.
- W4366179675 hasConceptScore W4366179675C98274493 @default.
- W4366179675 hasIssue "5" @default.
- W4366179675 hasLocation W43661796751 @default.
- W4366179675 hasOpenAccess W4366179675 @default.
- W4366179675 hasPrimaryLocation W43661796751 @default.
- W4366179675 hasRelatedWork W1980102165 @default.
- W4366179675 hasRelatedWork W2003866428 @default.
- W4366179675 hasRelatedWork W2046477662 @default.
- W4366179675 hasRelatedWork W2069597177 @default.
- W4366179675 hasRelatedWork W2120715038 @default.
- W4366179675 hasRelatedWork W2156094804 @default.
- W4366179675 hasRelatedWork W2302488404 @default.
- W4366179675 hasRelatedWork W3026393109 @default.
- W4366179675 hasRelatedWork W4205870591 @default.
- W4366179675 hasRelatedWork W4299601734 @default.
- W4366179675 hasVolume "143" @default.
- W4366179675 isParatext "false" @default.
- W4366179675 isRetracted "false" @default.
- W4366179675 workType "article" @default.