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- W4366180278 endingPage "944" @default.
- W4366180278 startingPage "944" @default.
- W4366180278 abstract "Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone. In most organisms, there is a cytoplasmic and mitochondrial thioredoxin system. A number of studies have examined the role of thioredoxin and thioredoxin reductase in determining longevity. Disruption of either thioredoxin or thioredoxin reductase is sufficient to shorten lifespan in model organisms including yeast, worms, flies and mice, thereby indicating conservation across species. Similarly, increasing the expression of thioredoxin or thioredoxin reductase can extend longevity in multiple model organisms. In humans, there is an association between a specific genetic variant of thioredoxin reductase and lifespan. Overall, the cytoplasmic and mitochondrial thioredoxin systems are both important for longevity." @default.
- W4366180278 created "2023-04-19" @default.
- W4366180278 creator A5047648680 @default.
- W4366180278 creator A5071125340 @default.
- W4366180278 date "2023-04-17" @default.
- W4366180278 modified "2023-09-26" @default.
- W4366180278 title "Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity" @default.
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