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- W4366181344 abstract "Environmental proteases have been suggested that promote sensitization and exacerbation in allergic diseases. Herein, we established and analyzed a new severe dermatitis model with epicutaneous administration of a model protease antigen, papain, which belongs to the same cysteine protease family with mite major allergens and staphylococcal proteases, via skin treated with a detergent, sodium dodecyl sulfate (SDS), which showed chronic skin inflammation associated with barrier dysfunction and itch, serum antigen-specific IgE elevation, differentiation of skin draining lymph node Th cells producing Th2/Th9/Th17/Th22/Th1 cytokines and subsequent airway inflammation induced by intranasal antigen challenge. Interestingly, analysis using protease inhibitor-treated papain demonstrated that protease activity of papain on SDS-affected skin was essential for exacerbated symptoms of the dermatitis, antigen-specific Th17/Th22 and Th1 differentiation and acceleration of IgE induction but, unexpectedly, was dispensable for Th2 and Th9 differentiation and subsequent allergic airway inflammation in the model. Additionally, epicutaneous administration of a non-protease model antigen, ovalbumin, did not show the responses, indicating that capacities to induce adaptive immune responses differ between protease inhibitor-treated papain and ovalbumin. The model would be useful for elucidation of unknown mechanisms for epicutaneous sensitization and itch-associated skin inflammation caused by stimulation with protease allergens or staphylococcal proteases on detergent-affected skin." @default.
- W4366181344 created "2023-04-19" @default.
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- W4366181344 date "2023-05-01" @default.
- W4366181344 modified "2023-09-28" @default.
- W4366181344 title "1586 Antigen protease activity with detergent is responsible to severe skin inflammation with itch and robust Th17/Th22 but not Th2 differentiation in mice" @default.
- W4366181344 doi "https://doi.org/10.1016/j.jid.2023.03.1604" @default.
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