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- W4366181566 abstract "Staphylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis (AD). A clear role for T-cells in immunity to S. aureus skin infections has been well established. Although Mucosal Associated Invariant T (MAIT) cells have been shown to reside in human and murine skin, their contribution to AD in the context of S. aureus infections has not yet been determined. Recent studies have now clearly shown that alterations in cellular metabolism influence the function of immune cells, and conversely, the immune cell function determines the cellular metabolic state. Therefore, in this study, we sought to determine the functional role and metabolic state of MAIT cells in S. aureus infections in the skin. MAIT cells were increased in the skin when a mouse model of S. aureus epicutaneous (e.c.) exposure produced AD-like skin inflammation but not in a mouse of intradermal (i.d) exposure. Furthermore, flow cytometry analysis of core metabolic pathways, such as glycolysis, oxidative phosphorylation (OXPHOS), and pentose phosphate pathway (PPP), demonstrated metabolic differences in S aureus mediated activation of MAIT cells in the epicutaneous mouse model. S aureus-activated MAIT cells in the skin enter the pentose phosphate pathway with increased Glucose transporter 1 (Glut-1) and Glucose 6 phosphate Dehydrogenase (G6PD) expression. The muti-parametric, high-dimensional flow cytometric analysis identified a unique subset of MAIT cells with a functional phenotypic expression of inflammatory markers with increased IL-17 and TNF but not IFN-g expression. Collectively, this study defines a previously unknown role of MAIT cells in S. aureus epicutaneous exposure. We show a functional role of MAIT cells that promotes skin inflammation with a PPP-dependent metabolic, inflammatory T-cell response." @default.
- W4366181566 created "2023-04-19" @default.
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- W4366181566 date "2023-05-01" @default.
- W4366181566 modified "2023-09-26" @default.
- W4366181566 title "179 Epicutaneous S. aureus increases mucosal associated invariant T (MAIT) cells that enter the pentose phosphate pathway (PPP) with increased IL-17 and TNF but not IFN-γ expression in the skin" @default.
- W4366181566 doi "https://doi.org/10.1016/j.jid.2023.03.180" @default.
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