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- W4366182010 abstract "CXCL14, a member of CXC chemokines, is produced by epidermal keratinocytes, dermal fibroblasts and vascular endothelial cells in the skin and recruits natural killer cells, macrophages, and dendritic cells. Although the chemotactic properties of CXCL14 is widely known, the naïve receptor of CXCL14 remains not yet fully characterized. Other than chemotaxis of immune cells, CXCL14 has the capacity to suppress angiogenesis by hindering chemotaxis of endothelial cells, exert antimicrobial activity, and inhibit CXCL12-CXCR4 interaction through CXCR4 internalization. Despite such various functions of CXCL14, its expression and association with disease development have not been studied in inflammatory skin disorders. Psoriasis is a chronic inflammatory skin disease presenting multiple erythematous keratotic patches, which significantly affects the quality of life. Although biologics such as anti-TNF-α inhibitors, anti-IL-17 inhibitors, and anti-IL-23 inhibitors are available for the treatment of psoriasis, further analysis of pathogenesis is desired. In this study, we examined CXCL14 expression in psoriasis patients to investigate the involvement of CXCL14 in the disease. We first examined CXCL14 expression in lesional skin by immunohistochemistry and found that CXCL14 expression in epidermal keratinocytes was decreased in psoriasis patients. We also measured serum CXCL14 levels in psoriasis patients under treatment. Serum CXCL14 levels in patients treated with oral drugs were lower than those in patients treated with topical therapies, whereas CXCL14 levels in patients treated with narrow band UVB therapy tended to be higher. Decreased CXCL14 expression in psoriasis may promote CXCL12-CXCR4 axis and angiogenesis, resulting in the exacerbation of psoriasis and narrow band UVB therapy may suppress the disease partially via upregulating CXCL14 expression." @default.
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- W4366182010 date "2023-05-01" @default.
- W4366182010 modified "2023-09-28" @default.
- W4366182010 title "1560 CXCL14 expression in psoriasis" @default.
- W4366182010 doi "https://doi.org/10.1016/j.jid.2023.03.1578" @default.
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