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- W4366182198 abstract "Human GWAS studies have identified association of single nucleotide polymorphisms in the secreted Wnt inhibitor genes DKK2 and SOSTDC1 with male pattern baldness. Expression of both genes localizes to the dermal papilla of human scalp hair follicles; however, their functions in controlling postnatal hair growth are unclear. Analysis of mouse dorsal skin shows that Dkk2 and Sostdc1 initiate strong expression in the hair follicle dermal papilla beginning at the onset of the first catagen regression phase (postnatal day 17). Both genes remain expressed in the dermal papilla through subsequent hair cycles, but Dkk2 has comparatively lower expression in anagen compared with telogen dermal papilla. To determine the functions of Dkk2 and Sostdc1 in postnatal hair growth we analyzed timing of the hair follicle growth cycle in mice globally lacking either one or both inhibitors. Mice with deletion of either Dkk2 or Sostdc1 alone displayed normal timing of the hair follicle growth cycle. By contrast, co-deletion of Dkk2 and Sostdc1 caused a significant delay in onset of the first catagen phase. These data demonstrate that DKK2 and SOSTDC1 are co-required for normal timing of the first catagen phase and reveal a key role for Wnt inhibition in hair follicle growth cycle timing. Our results further suggest that blocking the actions of Wnt inhibitors may be an effective method to prolong anagen for therapeutic purposes." @default.
- W4366182198 created "2023-04-19" @default.
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- W4366182198 date "2023-05-01" @default.
- W4366182198 modified "2023-09-28" @default.
- W4366182198 title "1428 DKK2 and SOSTDC1 cooperate to initiate the first catagen phase of the hair follicle growth cycle" @default.
- W4366182198 doi "https://doi.org/10.1016/j.jid.2023.03.1444" @default.
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