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• W4366182218 abstract "Hair follicles (HFs) of mammalian epidermis undergo cyclic bouts of regeneration to continuously form new hairs. Stem cells (SCs) in the bulge and hair germ fuel the hair regeneration cycle that comprises three phases: (1) growth (anagen), where SCs proliferate to generate the new hair shaft; (2) regression (catagen), where part of the HF keratinocytes undergo apoptosis and surviving cells move upwards; and (3) rest (telogen), where SCs are quiescent. Skin is dramatically remodeled during catagen, which is a crucial phase for the re-establishment of the new SC niche. However, the role of cell death and the underlying cellular and molecular mechanisms are still not well understood. Here, we investigate the impact of defective apoptosis on hair regeneration and skin remodeling. In particular, we aimed to interfere with HF regression by overexpressing the anti-apoptotic protein Bcl-2 in murine epidermis (Bcl-2EOE mice). Bcl-2EOE mice display a block in cell death specifically during catagen. The increase in HF cell survival led to the formation of an enlarged HF bulge and a change in the SC niche architecture during telogen. As a result, the following hair regeneration cycle was delayed, due to a stall in the SC proliferation at anagen onset. Mechanistically, telogen prolongation correlated with an upregulation of quiescence markers and a decrease in anagen-activating signals. Intriguingly, the dermal white adipose tissue was abnormally regulated in Bcl-2EOE mice, displaying accelerated lipolysis and thinning of the adipocyte layer during catagen. To understand how HF cell death may affect skin remodeling during catagen, we conducted scRNA-Seq on Bcl-2EOEand control skin, investigating the cellular crosstalk between keratinocytes and other tissues. Taken together, our data demonstrate that a proper regulation of cell death during the hair cycle is required for the establishment and function of the HF SC niche. Importantly, our model gives new insights into cell autonomous and non-autonomous mechanisms of hair regeneration and tissue remodeling." @default.
• W4366182218 created "2023-04-19" @default.
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• W4366182218 date "2023-05-01" @default.
• W4366182218 modified "2023-09-28" @default.
• W4366182218 title "1391 Cell death functions in hair follicle regeneration" @default.
• W4366182218 doi "https://doi.org/10.1016/j.jid.2023.03.1407" @default.
• W4366182218 hasPublicationYear "2023" @default.
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