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- W4366183206 abstract "We have investigated the expression and the localization of histidine decarboxylase (HDC, a key enzyme for histamine biosynthesis) in human skin by immunohistochemical analysis. HDC-immunoreactive and cytokeratin 14-non immunoreactive cells were observed around the basal layer of the epidermis of healthy subjects and patients with atopic dermatitis (AD). These cells did not express mast cell-tryptase but expressed tyrosinase and microphthalmia-associated transcription factor. Moreover, HDC mRNA and proteins were detected in cultured normal human epidermal melanocytes, suggesting that HDC-immunoreactive and cytokeratin 14-non immunoreactive cells are melanocytes. Furthermore, HDC-immunoreactive and cytokeratin 10-non immunoreactive cells were also detected in the suprabasal layers of the epidermis in patients with AD, which expressed CD1a, suggesting that these cells are Langerhans cells. In addition, we found that HDC expression was observed in the sweat glands of healthy subjects and patients with AD and that the levels of its expression in patients with AD was higher than that of healthy subjects. In these studies, we presumed that melanocytes, Langerhans cells, and sweat glands themselves can produce histamine, suggesting that potential new sources of histamine in chronic skin inflammations, such as AD." @default.
- W4366183206 created "2023-04-19" @default.
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- W4366183206 date "2023-05-01" @default.
- W4366183206 modified "2023-09-28" @default.
- W4366183206 title "1414 iPotential sources of new histamine-producing cells in the skin of patients with atopic dermatits" @default.
- W4366183206 doi "https://doi.org/10.1016/j.jid.2023.03.1430" @default.
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