Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366183229> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4366183229 endingPage "S238" @default.
- W4366183229 startingPage "S238" @default.
- W4366183229 abstract "Background: The involvement of sweat glands in preventing dry skin in mice has been suggested. We previously demonstrated that inoculating the thigh of wild-type immunocompetent C57BL/6J (B6) mice with cutaneous herpes simplex virus-1 (HSV-1) led to infection of the sweat glands, which in turn caused sweating disturbance followed by the development of dry skin. Interestingly, HSV-1–inoculated mice that recovered from the sweating disturbance showed neither HSV-1–induced zoster-like skin lesions nor significant sweating disturbance by second inoculation of HSV-1, suggesting that the principal driver of protection was immunity against HSV-1. Objective: We investigated whether anti-HSV-1 antibodies protect mice from sweating disturbance and the development of zoster-like lesions. Methods: We injected serum into the footpads of mice following the inoculation of HSV-1 at thigh. Using the impression mold technique and real-time PCR, we examined the sweating response together with the detection of HSV-1 DNA in the skin, sweat glands, and dorsal root ganglia (DRG) in B6 mice. Results: Resistance of the sweat glands to HSV-1 was proportional to serum anti-HSV IgG titers. Local percutaneous injection with antisera from mice inoculated with either live HSV-1 or heat-inactivated HSV-1 7 days earlier protected against the development of zoster-like skin lesions and sweating disturbance, while that with control sera showed no such protection. This treatment also prevented viral spread and replication in the sweat glands and DRG; not only the sweat glands but also the keratinocytes were protected from tissue damage by prior local percutaneous injection with anti-HSV sera. Conclusion: Local percutaneous injection with anti-HSV sera to any site provided long-term protection against the induction of zoster-like skin lesions and sweating disturbance–induced dry skin through subsequent HSV-1 challenge." @default.
- W4366183229 created "2023-04-19" @default.
- W4366183229 creator A5023263338 @default.
- W4366183229 creator A5035358364 @default.
- W4366183229 creator A5043933597 @default.
- W4366183229 creator A5071609471 @default.
- W4366183229 creator A5077587367 @default.
- W4366183229 creator A5079817803 @default.
- W4366183229 date "2023-05-01" @default.
- W4366183229 modified "2023-09-28" @default.
- W4366183229 title "1389 Local injection with anti-herpes simplex virus antibodies protects against development of herpes simplex virus–induced sweating disturbance" @default.
- W4366183229 doi "https://doi.org/10.1016/j.jid.2023.03.1405" @default.
- W4366183229 hasPublicationYear "2023" @default.
- W4366183229 type Work @default.
- W4366183229 citedByCount "0" @default.
- W4366183229 crossrefType "journal-article" @default.
- W4366183229 hasAuthorship W4366183229A5023263338 @default.
- W4366183229 hasAuthorship W4366183229A5035358364 @default.
- W4366183229 hasAuthorship W4366183229A5043933597 @default.
- W4366183229 hasAuthorship W4366183229A5071609471 @default.
- W4366183229 hasAuthorship W4366183229A5077587367 @default.
- W4366183229 hasAuthorship W4366183229A5079817803 @default.
- W4366183229 hasBestOaLocation W43661832291 @default.
- W4366183229 hasConcept C126322002 @default.
- W4366183229 hasConcept C159047783 @default.
- W4366183229 hasConcept C159654299 @default.
- W4366183229 hasConcept C180032290 @default.
- W4366183229 hasConcept C203014093 @default.
- W4366183229 hasConcept C2522874641 @default.
- W4366183229 hasConcept C2781196997 @default.
- W4366183229 hasConcept C32611913 @default.
- W4366183229 hasConcept C63398376 @default.
- W4366183229 hasConcept C71924100 @default.
- W4366183229 hasConcept C86803240 @default.
- W4366183229 hasConceptScore W4366183229C126322002 @default.
- W4366183229 hasConceptScore W4366183229C159047783 @default.
- W4366183229 hasConceptScore W4366183229C159654299 @default.
- W4366183229 hasConceptScore W4366183229C180032290 @default.
- W4366183229 hasConceptScore W4366183229C203014093 @default.
- W4366183229 hasConceptScore W4366183229C2522874641 @default.
- W4366183229 hasConceptScore W4366183229C2781196997 @default.
- W4366183229 hasConceptScore W4366183229C32611913 @default.
- W4366183229 hasConceptScore W4366183229C63398376 @default.
- W4366183229 hasConceptScore W4366183229C71924100 @default.
- W4366183229 hasConceptScore W4366183229C86803240 @default.
- W4366183229 hasIssue "5" @default.
- W4366183229 hasLocation W43661832291 @default.
- W4366183229 hasOpenAccess W4366183229 @default.
- W4366183229 hasPrimaryLocation W43661832291 @default.
- W4366183229 hasRelatedWork W1561127041 @default.
- W4366183229 hasRelatedWork W1861344368 @default.
- W4366183229 hasRelatedWork W1921623483 @default.
- W4366183229 hasRelatedWork W1972745941 @default.
- W4366183229 hasRelatedWork W2022308173 @default.
- W4366183229 hasRelatedWork W2028284080 @default.
- W4366183229 hasRelatedWork W2070480238 @default.
- W4366183229 hasRelatedWork W2132880522 @default.
- W4366183229 hasRelatedWork W2409733744 @default.
- W4366183229 hasRelatedWork W2902888867 @default.
- W4366183229 hasVolume "143" @default.
- W4366183229 isParatext "false" @default.
- W4366183229 isRetracted "false" @default.
- W4366183229 workType "article" @default.