Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366183245> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4366183245 endingPage "S235" @default.
- W4366183245 startingPage "S235" @default.
- W4366183245 abstract "The RNA-binding protein YBX1 (Y-box binding protein-1) is an epidermal stem cell function regulator. Loss of YBX1 expression in keratinocytes results in a decrease in the proliferative potential of epidermal progenitors in vitro and alterations in all of the epidermal lineages in vivo. YBX1 binds the 3’UTR of multiple targets in epidermal stem cells, inhibits the translation of potent senescence-associated cytokines guarding the cells against the occurrence of senescence, and mediates stem cells' self-renewal and proliferation. Previous studies have shown that phosphorylation of YBX1 can diminish its RNA binding affinity. Here we show that phosphorylated YBX1 in epidermal stem cells isolated from donors of different ages is elevated. Small molecule inhibitors of PI3 kinase (PI3K), such as PI-103 and GDC-0941 inhibit YBX1 phosphorylation levels in epidermal stem cells and consequently reduce the occurrence of cellular senescence in primary epidermal stem cells isolated from adult donors. Furthermore, PI3K inhibitors increase the speed of epidermal wound closure in a wound healing model and epidermal regeneration model utilizing 3D skin equivalents. Our findings have uncovered a new level of posttranscriptional control of aging epidermal stem cell function by YBX1, which is required to maintain epidermal regenerative potential." @default.
- W4366183245 created "2023-04-19" @default.
- W4366183245 creator A5003470460 @default.
- W4366183245 creator A5007562323 @default.
- W4366183245 creator A5022681604 @default.
- W4366183245 creator A5054799268 @default.
- W4366183245 date "2023-05-01" @default.
- W4366183245 modified "2023-09-28" @default.
- W4366183245 title "1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function" @default.
- W4366183245 doi "https://doi.org/10.1016/j.jid.2023.03.1388" @default.
- W4366183245 hasPublicationYear "2023" @default.
- W4366183245 type Work @default.
- W4366183245 citedByCount "0" @default.
- W4366183245 crossrefType "journal-article" @default.
- W4366183245 hasAuthorship W4366183245A5003470460 @default.
- W4366183245 hasAuthorship W4366183245A5007562323 @default.
- W4366183245 hasAuthorship W4366183245A5022681604 @default.
- W4366183245 hasAuthorship W4366183245A5054799268 @default.
- W4366183245 hasBestOaLocation W43661832451 @default.
- W4366183245 hasConcept C11960822 @default.
- W4366183245 hasConcept C170493617 @default.
- W4366183245 hasConcept C201750760 @default.
- W4366183245 hasConcept C203014093 @default.
- W4366183245 hasConcept C2776362946 @default.
- W4366183245 hasConcept C2780269544 @default.
- W4366183245 hasConcept C28328180 @default.
- W4366183245 hasConcept C502942594 @default.
- W4366183245 hasConcept C522857546 @default.
- W4366183245 hasConcept C55493867 @default.
- W4366183245 hasConcept C86803240 @default.
- W4366183245 hasConcept C95444343 @default.
- W4366183245 hasConceptScore W4366183245C11960822 @default.
- W4366183245 hasConceptScore W4366183245C170493617 @default.
- W4366183245 hasConceptScore W4366183245C201750760 @default.
- W4366183245 hasConceptScore W4366183245C203014093 @default.
- W4366183245 hasConceptScore W4366183245C2776362946 @default.
- W4366183245 hasConceptScore W4366183245C2780269544 @default.
- W4366183245 hasConceptScore W4366183245C28328180 @default.
- W4366183245 hasConceptScore W4366183245C502942594 @default.
- W4366183245 hasConceptScore W4366183245C522857546 @default.
- W4366183245 hasConceptScore W4366183245C55493867 @default.
- W4366183245 hasConceptScore W4366183245C86803240 @default.
- W4366183245 hasConceptScore W4366183245C95444343 @default.
- W4366183245 hasIssue "5" @default.
- W4366183245 hasLocation W43661832451 @default.
- W4366183245 hasOpenAccess W4366183245 @default.
- W4366183245 hasPrimaryLocation W43661832451 @default.
- W4366183245 hasRelatedWork W1987384599 @default.
- W4366183245 hasRelatedWork W2048957342 @default.
- W4366183245 hasRelatedWork W2111214065 @default.
- W4366183245 hasRelatedWork W2135793203 @default.
- W4366183245 hasRelatedWork W2168144313 @default.
- W4366183245 hasRelatedWork W2300366807 @default.
- W4366183245 hasRelatedWork W2801524442 @default.
- W4366183245 hasRelatedWork W2942732239 @default.
- W4366183245 hasRelatedWork W3213450778 @default.
- W4366183245 hasRelatedWork W3563801 @default.
- W4366183245 hasVolume "143" @default.
- W4366183245 isParatext "false" @default.
- W4366183245 isRetracted "false" @default.
- W4366183245 workType "article" @default.