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- W4366183266 abstract "Skin aging, represented by increased rigidity, wrinkles, and impaired wound healing of the skin, is mainly attributed to abnormal collagen homeostasis with decreased synthesis and increased degradation. There is increasing evidence that particulate matter (PM), the major component of air pollution, is involved in skin aging and cellular senescence. Here, we performed high-throughput single-cell RNA sequencing using ex vivo human skin tissues with or without PM exposure to screen out candidate molecules associated with skin aging. Through R-based bioinformatic analysis, differentially expressed genes (DEGs) were evaluated in each skin cell type. Among several DEGs, IL-24 was selected to evaluate its role regarding skin aging because IL-24 was highly upregulated in both keratinocytes and fibroblasts simultaneously by PM treatment. In the skin, IL-24 is known to affect the expression of pro-inflammatory mediators via JAK/STAT3 pathway and wound chronicity by interfering with the migration of keratinocytes via AKT-dependent pathway. However, the known activity of IL-24 in skin aging is limited. Our study presents an increased expression of IL-24 in keratinocytes and fibroblasts by PM treatment and keratinocytes as a major source of IL-24 by PM. Further, PM-induced IL-24 from keratinocytes not only increased the expression of MMP1 but also reduced type I collagen production, similar to the age-related biochemical changes in the dermal skins. Also, we found that repeated treatment with IL-24 for more than 3 weeks induced fibroblast senescence. We believe this data shed light on the pathogenesis of PM-induced skin aging, and the results could be utilized to develop future therapeutic targets against PM-induced aging." @default.
- W4366183266 created "2023-04-19" @default.
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- W4366183266 date "2023-05-01" @default.
- W4366183266 modified "2023-09-30" @default.
- W4366183266 title "1396 Interferon-24 regulates the expression of MMP1 and dermal collagen of the skin" @default.
- W4366183266 doi "https://doi.org/10.1016/j.jid.2023.03.1412" @default.
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