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- W4366184230 abstract "Melanocytes are pigmentary generated cells in epidermis and initiate the melanin synthesis through melanogenesis upon receiving the external stimulation. Melanogenesis represents the process of melanin maturation, and the melanin can be accumulated in cytosol or secret to extracellular space. Imiquimod (IMQ) is a FDA-approved TLR7 ligand and uses for treatment of skin cancers and genital warts in clinical through activation of cell-specific immune response. High concentration of IMQ also directly induces cancer cell death. In this study, we will explore the mechanism of melanogenesis in IMQ-induced melanogenesis in melanoma cells. First, we demonstrated that the low dosage of IMQ could induce melanogenesis, melanin production and secretion in murine B16F10 melanoma cells. IMQ induces nuclear translocation of transcription factor MITF, upregulates the expression of melanogenesis-related proteins, increases tyrosinase activity, and leads to pigmentation in B16F10 cells. Next, we observed that IMQ-induced melanogenesis depends on PKA activation which triggered by excessive intracellular cAMP accumulation. The cAMP accumulation is contributed by TLR7-independent and ROS-mediated PDE4B inhibition. Finally, we demonstrated that the TLR7 also plays a critical role in IMQ-induced melanogenesis by using TLR7 inhibitor and TLR7 knockdown strategy. Taken together, we provide the evidence that low dosage of IMQ can trigger melanogenesis through both TLR7-dependent and -independent pathways in B16F10 melanoma cells." @default.
- W4366184230 created "2023-04-19" @default.
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- W4366184230 date "2023-05-01" @default.
- W4366184230 modified "2023-09-28" @default.
- W4366184230 title "1207 Low dosage of imiquimod induces melanogenesis in melanoma cells through the ROS and TLR7 signal" @default.
- W4366184230 doi "https://doi.org/10.1016/j.jid.2023.03.1221" @default.
- W4366184230 hasPublicationYear "2023" @default.
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