Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366184467> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4366184467 endingPage "S205" @default.
- W4366184467 startingPage "S205" @default.
- W4366184467 abstract "Melanoma is the most aggressive skin cancer and is responsible for the majority of skin cancer deaths. Despite advances in treatment, our current prognostic indicators are poor and fail to adequately risk-stratify our patients. This study evaluates the concentration, size, proteomic and metabolomic profile of circulating extracellular vesicles (EVs) isolated from the plasma of patients with melanoma, to identify potential biomarkers of disease and progression. This clinical cohort =study recruited n=36 patients with melanoma and n=13 healthy controls and isolated the EVs from their plasma using a clinically applicable technique - Size Exclusion Chromatography (SEC). EVs were then characterized according to the Minimal Information for Studies of Extracellular Vesicles guidelines (2018). Nanoparticle Tracking analysis demonstrated an increase in the concentration of EVs isolated from the plasma of patients with melanoma in comparison to healthy controls (p=0.002), though no significant difference in the concentration between those with primary and metastatic melanoma. No significant difference was detected in the modal size or protein concentration of EVs between groups. Proteomic profiling robustly identified over 300 proteins within the EVs and 88 metabolites, with variations in profiles demonstrated between those with metastatic and primary disease, and compared to healthy controls. This work further supports the potential role of EVs as diagnostic biomarkers in melanoma and gives insight into the targets for further study." @default.
- W4366184467 created "2023-04-19" @default.
- W4366184467 creator A5003874766 @default.
- W4366184467 creator A5009477818 @default.
- W4366184467 creator A5015262540 @default.
- W4366184467 creator A5024589324 @default.
- W4366184467 creator A5026951827 @default.
- W4366184467 creator A5029480265 @default.
- W4366184467 creator A5036771859 @default.
- W4366184467 creator A5061956666 @default.
- W4366184467 creator A5077939705 @default.
- W4366184467 creator A5080331399 @default.
- W4366184467 creator A5091562783 @default.
- W4366184467 date "2023-05-01" @default.
- W4366184467 modified "2023-09-30" @default.
- W4366184467 title "1196 Circulating extracellular vesicles of patients with melanoma differ in concentration and composition compared to healthy controls" @default.
- W4366184467 doi "https://doi.org/10.1016/j.jid.2023.03.1210" @default.
- W4366184467 hasPublicationYear "2023" @default.
- W4366184467 type Work @default.
- W4366184467 citedByCount "0" @default.
- W4366184467 crossrefType "journal-article" @default.
- W4366184467 hasAuthorship W4366184467A5003874766 @default.
- W4366184467 hasAuthorship W4366184467A5009477818 @default.
- W4366184467 hasAuthorship W4366184467A5015262540 @default.
- W4366184467 hasAuthorship W4366184467A5024589324 @default.
- W4366184467 hasAuthorship W4366184467A5026951827 @default.
- W4366184467 hasAuthorship W4366184467A5029480265 @default.
- W4366184467 hasAuthorship W4366184467A5036771859 @default.
- W4366184467 hasAuthorship W4366184467A5061956666 @default.
- W4366184467 hasAuthorship W4366184467A5077939705 @default.
- W4366184467 hasAuthorship W4366184467A5080331399 @default.
- W4366184467 hasAuthorship W4366184467A5091562783 @default.
- W4366184467 hasBestOaLocation W43661844671 @default.
- W4366184467 hasConcept C104317684 @default.
- W4366184467 hasConcept C121608353 @default.
- W4366184467 hasConcept C126322002 @default.
- W4366184467 hasConcept C143998085 @default.
- W4366184467 hasConcept C145059251 @default.
- W4366184467 hasConcept C146304588 @default.
- W4366184467 hasConcept C20518536 @default.
- W4366184467 hasConcept C2777658100 @default.
- W4366184467 hasConcept C2777789703 @default.
- W4366184467 hasConcept C2778120352 @default.
- W4366184467 hasConcept C2779134260 @default.
- W4366184467 hasConcept C2781197716 @default.
- W4366184467 hasConcept C28406088 @default.
- W4366184467 hasConcept C2908689518 @default.
- W4366184467 hasConcept C2992929900 @default.
- W4366184467 hasConcept C502942594 @default.
- W4366184467 hasConcept C55493867 @default.
- W4366184467 hasConcept C71924100 @default.
- W4366184467 hasConcept C72563966 @default.
- W4366184467 hasConcept C86803240 @default.
- W4366184467 hasConcept C95444343 @default.
- W4366184467 hasConceptScore W4366184467C104317684 @default.
- W4366184467 hasConceptScore W4366184467C121608353 @default.
- W4366184467 hasConceptScore W4366184467C126322002 @default.
- W4366184467 hasConceptScore W4366184467C143998085 @default.
- W4366184467 hasConceptScore W4366184467C145059251 @default.
- W4366184467 hasConceptScore W4366184467C146304588 @default.
- W4366184467 hasConceptScore W4366184467C20518536 @default.
- W4366184467 hasConceptScore W4366184467C2777658100 @default.
- W4366184467 hasConceptScore W4366184467C2777789703 @default.
- W4366184467 hasConceptScore W4366184467C2778120352 @default.
- W4366184467 hasConceptScore W4366184467C2779134260 @default.
- W4366184467 hasConceptScore W4366184467C2781197716 @default.
- W4366184467 hasConceptScore W4366184467C28406088 @default.
- W4366184467 hasConceptScore W4366184467C2908689518 @default.
- W4366184467 hasConceptScore W4366184467C2992929900 @default.
- W4366184467 hasConceptScore W4366184467C502942594 @default.
- W4366184467 hasConceptScore W4366184467C55493867 @default.
- W4366184467 hasConceptScore W4366184467C71924100 @default.
- W4366184467 hasConceptScore W4366184467C72563966 @default.
- W4366184467 hasConceptScore W4366184467C86803240 @default.
- W4366184467 hasConceptScore W4366184467C95444343 @default.
- W4366184467 hasIssue "5" @default.
- W4366184467 hasLocation W43661844671 @default.
- W4366184467 hasOpenAccess W4366184467 @default.
- W4366184467 hasPrimaryLocation W43661844671 @default.
- W4366184467 hasRelatedWork W2504108804 @default.
- W4366184467 hasRelatedWork W2760292854 @default.
- W4366184467 hasRelatedWork W2887491815 @default.
- W4366184467 hasRelatedWork W2905073085 @default.
- W4366184467 hasRelatedWork W2917685500 @default.
- W4366184467 hasRelatedWork W3029637598 @default.
- W4366184467 hasRelatedWork W3032861598 @default.
- W4366184467 hasRelatedWork W3189276748 @default.
- W4366184467 hasRelatedWork W4313365844 @default.
- W4366184467 hasRelatedWork W81983803 @default.
- W4366184467 hasVolume "143" @default.
- W4366184467 isParatext "false" @default.
- W4366184467 isRetracted "false" @default.
- W4366184467 workType "article" @default.