Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366184472> ?p ?o ?g. }
- W4366184472 abstract "Heart failure with preserved ejection fraction (HFpEF) is increasingly recognised to be strongly associated with obesity and abnormalities in fat distribution. Epicardial fat has been associated with abnormal haemodynamics in HFpEF, with potential for direct mechanical effects on the heart causing constriction-like physiology and local myocardial remodelling effects from secretion of inflammatory and profibrotic mediators. However, patients with epicardial fat generally have more systemic and visceral adipose tissue making determination of causality between epicardial fat and HFpEF complex. In this review, we will summarise the evidence for epicardial fat being either directly causal in HFpEF pathogenesis or merely being a correlate of worse systemic inflammatory and generalised adiposity. We will also discuss therapies that directly target epicardial fat and may have potential for treating HFpEF and elucidating the independent role of epicardial fat in its pathogenesis." @default.
- W4366184472 created "2023-04-19" @default.
- W4366184472 creator A5012701510 @default.
- W4366184472 creator A5031317277 @default.
- W4366184472 creator A5070217133 @default.
- W4366184472 date "2023-04-15" @default.
- W4366184472 modified "2023-09-26" @default.
- W4366184472 title "Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around?" @default.
- W4366184472 cites W123270545 @default.
- W4366184472 cites W1500521086 @default.
- W4366184472 cites W1738779435 @default.
- W4366184472 cites W1799012230 @default.
- W4366184472 cites W1900043612 @default.
- W4366184472 cites W1963940525 @default.
- W4366184472 cites W1994291717 @default.
- W4366184472 cites W1995657433 @default.
- W4366184472 cites W2017221955 @default.
- W4366184472 cites W2022892320 @default.
- W4366184472 cites W2049514014 @default.
- W4366184472 cites W2052264647 @default.
- W4366184472 cites W2062571251 @default.
- W4366184472 cites W2064130493 @default.
- W4366184472 cites W2069083686 @default.
- W4366184472 cites W2070350109 @default.
- W4366184472 cites W2070853893 @default.
- W4366184472 cites W2072168595 @default.
- W4366184472 cites W2077042841 @default.
- W4366184472 cites W2077284152 @default.
- W4366184472 cites W2098267336 @default.
- W4366184472 cites W2102904190 @default.
- W4366184472 cites W2106914263 @default.
- W4366184472 cites W2109677274 @default.
- W4366184472 cites W2114484288 @default.
- W4366184472 cites W2139959600 @default.
- W4366184472 cites W2142830692 @default.
- W4366184472 cites W2160768602 @default.
- W4366184472 cites W2215494512 @default.
- W4366184472 cites W2231944090 @default.
- W4366184472 cites W2313998826 @default.
- W4366184472 cites W2335973015 @default.
- W4366184472 cites W2337473245 @default.
- W4366184472 cites W2340995766 @default.
- W4366184472 cites W2343152331 @default.
- W4366184472 cites W2425644022 @default.
- W4366184472 cites W2505843168 @default.
- W4366184472 cites W2513264676 @default.
- W4366184472 cites W2519510391 @default.
- W4366184472 cites W2558296592 @default.
- W4366184472 cites W2560121711 @default.
- W4366184472 cites W2560766040 @default.
- W4366184472 cites W2580189755 @default.
- W4366184472 cites W2602132542 @default.
- W4366184472 cites W2604584410 @default.
- W4366184472 cites W2614739807 @default.
- W4366184472 cites W2616047952 @default.
- W4366184472 cites W2751654688 @default.
- W4366184472 cites W2781483265 @default.
- W4366184472 cites W2794362447 @default.
- W4366184472 cites W2804511116 @default.
- W4366184472 cites W2807970930 @default.
- W4366184472 cites W2809217674 @default.
- W4366184472 cites W2848993374 @default.
- W4366184472 cites W2871286142 @default.
- W4366184472 cites W2886821858 @default.
- W4366184472 cites W2888795779 @default.
- W4366184472 cites W2897696001 @default.
- W4366184472 cites W2898735259 @default.
- W4366184472 cites W2901009239 @default.
- W4366184472 cites W2937229868 @default.
- W4366184472 cites W2950377533 @default.
- W4366184472 cites W2953737182 @default.
- W4366184472 cites W2954863876 @default.
- W4366184472 cites W2961820858 @default.
- W4366184472 cites W2964628020 @default.
- W4366184472 cites W2979864371 @default.
- W4366184472 cites W2981125726 @default.
- W4366184472 cites W2985962366 @default.
- W4366184472 cites W2995420665 @default.
- W4366184472 cites W3004319546 @default.
- W4366184472 cites W3016784104 @default.
- W4366184472 cites W3022964818 @default.
- W4366184472 cites W3040934048 @default.
- W4366184472 cites W3041438146 @default.
- W4366184472 cites W3045989635 @default.
- W4366184472 cites W3081384105 @default.
- W4366184472 cites W3083985134 @default.
- W4366184472 cites W3109313492 @default.
- W4366184472 cites W3125530967 @default.
- W4366184472 cites W3127371223 @default.
- W4366184472 cites W3135812748 @default.
- W4366184472 cites W3137764073 @default.
- W4366184472 cites W3149750390 @default.
- W4366184472 cites W3151490690 @default.
- W4366184472 cites W3158123746 @default.
- W4366184472 cites W3165854356 @default.
- W4366184472 cites W3167489432 @default.
- W4366184472 cites W3177960627 @default.
- W4366184472 cites W3186811750 @default.
- W4366184472 cites W3188627338 @default.
- W4366184472 cites W3193297191 @default.