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- W4366184479 abstract "Decanoic acid is used as an additive in injections to prolong the action of drugs because of its lipid solubility. In addition, decanoic acid has been speculated to have anti-inflammatory effects. In this study, we examined its anti-inflammatory effects on a mouse model of dinitrofluorobenzene (DNFB)-induced irritant contact dermatitis. Mice were divided into four treatment groups. In Groups 1, mice were challenged with a twice application of 50μl of 0.5% DNFB on the abdomen for sensitization. Then, mice were challenged once on both ears with 20 μL of 0.5% DNFB to induce skin inflammation. In Group 2, mice were further treated with a single application of decanoic acid ointment in volume of 0.05 g surface of each ear 30 min later after challenge. In Group 3, mice were further treated with a single application of vaseline ointment instead of decanoic acid ointment in Group 2. In Group 4, mice were served as a control and 50μl of acetone was applied on the abdomen. Then 20μl of acetone was applied single to each ear. Ear thickness was measured at 0, 4, 8, 24, 48, 72 and 96 hours after ear challenge. In group 2 mice showed less ear thickness than in groups 1 and 3 mice (after DNFB challenge 72h: Group1, 515.00 ± 30.68 μm, Group2, 395.67 ± 11.26 μm, Group3, 435.14 ± 11.26 μm, 96h: Group1, 607.67 ± 73.23 μm, Group2, 426.50 ± 26.67 μm, Group3, 568.71 ± 47.70 μm.). These results suggest that decanoic acid ointment may have a therapeutic effect on inflammatory skin diseases. Additional experiments are underway to determine whether decanoic acid ointment has anti-inflammatory effects." @default.
- W4366184479 created "2023-04-19" @default.
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- W4366184479 date "2023-05-01" @default.
- W4366184479 modified "2023-09-28" @default.
- W4366184479 title "1102 Anti-inflammation effects of decanoic acid in a mouse of contact hypersensitivity: On a possible new drug for inflammatory skin disease" @default.
- W4366184479 doi "https://doi.org/10.1016/j.jid.2023.03.1114" @default.
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