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- W4366184879 abstract "Efficient treatment of hyperpigmentation involves targeting multiple stages of the melanin lifecycle. However, using several ingredients in one product may be complicated by delivery vehicle compatibility, leading to poor distribution and efficacy. This study characterized E&C, a topical multimodal pigment-correcting serum formulated in a novel hydropolymeric vehicle. Franz diffusion cells with cadaver skin were used to evaluate delivery of two key E&C ingredients after 24h at different doses: tranexamic acid(TXA), which has poor skin absorption, and phenyl ethyl resorcinol(PER), which has limited solubility. Effects on pigmentation were tested in the MelanoDerm™ 3D skin model. A dose-responsive increase in TXA delivery was seen at 1,3 and 6% TXA. More TXA accumulated in skin with E&C at 3% TXA compared to a commercially available product(CAP) with 3% TXA. E&C with 6% TXA led to 5 times more accumulation but similar transdermal flux vs. the CAP, showing the importance of an optimal vehicle for high retention with less potential for transdermal diffusion. E&C with 0.5% PER showed permeation in epidermis (mean±SD, 0.88±0.12 μg/cm2) with none detected in dermis, while E&C with 1% PER delivered more to epidermis (1.38±0.32 μg/cm2) and dermis (0.47±0.11 μg/cm2). A wider distribution allows for targeting melanocytes at the dermal-epidermal junction, and 1% PER showed greater melanin production inhibition in MelanoDerm™ vs. 0.5% PER. The final E&C formulation (6% TXA, 1% PER, and other actives) led to downregulation of genes in melanocyte activation, melanosome formation, melanin production, and melanosome transport vs. negative control tissue. E&C also led to a 55.8±1.8% reduction in melanin production, less melanin seen by Fontana-Masson staining, and fewer melanosomes transferred to keratinocytes seen by electron microscopy. Altogether, these results show inhibition of melanogenesis by E&C and highlight the topical vehicle’s role in maximizing delivery and biological activity." @default.
- W4366184879 created "2023-04-19" @default.
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- W4366184879 date "2023-05-01" @default.
- W4366184879 modified "2023-09-28" @default.
- W4366184879 title "1059 Development of a multi-modality pigment correcting hydropolymeric serum" @default.
- W4366184879 doi "https://doi.org/10.1016/j.jid.2023.03.1071" @default.
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