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- W4366185358 abstract "Sweat is important to preserve skin moisturized. However, sweat is known to exacerbate atopic dermatitis (AD), and only little attention has been paid to the sweat disturbance in patients with AD. To know characteristics of sweat disturbance in patients with AD, basal and thermo-reactive sweating at the forearm were analyzed by the Automatic Assessment for Skin Microstructure and Sweating (AAMS), which quantitates perspiration captured by the impression mold technique. The Atopic Dermatitis Sweat Function Registry (ADSF Registry) was established by the cooperation of 4 dermatology centers, and AAMS samples of 38 AD patients and 26 age-matched healthy controls (HC) were collected and registered with their clinical information. The analysis of ADSF registry revealed that the mean number of sweat droplets at skin fold in resting condition was low compared to HC, and that the mean number of sweat droplets at skin ridges was high, in relation to the progression of skin roughness. Moreover, the mean number of sweat droplets at skin ridges in AD skin did not change from baseline after thermal stimulus, whereas that in HC significantly increased. Thus, sweating function of AD patients is significantly impaired compared to that of HC, both in basal and thermo-reactive conditions. The ADSF Registry using AAMS may be a powerful platform for further studies of sweating by AD patients." @default.
- W4366185358 created "2023-04-19" @default.
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- W4366185358 date "2023-05-01" @default.
- W4366185358 modified "2023-09-28" @default.
- W4366185358 title "1357 Construction of the atopic dermatitis sweat function registry (ADSF Registry) for sweating disturbance in atopic dermatitis evaluated by automatic assessment for skin microstructure and sweating" @default.
- W4366185358 doi "https://doi.org/10.1016/j.jid.2023.03.1373" @default.
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