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- W4366185383 abstract "Background and Objective: Adapalene/benzoyl peroxide gel (ADP/BPO) and benzoyl peroxide gel (BPO) are recommended for the treatment of acne vulgaris during the acute inflammatory phase and for maintenance therapy after inflammation has subsided. As an advantage of continued maintenance treatment, it is expected that atrophic scar formation will be reduced by maintaining remission after inflammation has subsided. The purpose of this study was to investigate the usefulness of maintenance therapy with anti-acne drugs and its effect on the suppression of atrophic scars. Method, and Results: This was a multicenter, open-label, randomized, group-controlled study with an observation period of 24 weeks. 126 patients were randomly assigned to the ADP/BPO group (n=40), BPO group (n=44), or control group (n=42). The primary endpoint, the treatment success rate of maintenance therapy was 89.2% in the ADP/BPO group, 87.5% in the BPO group, and 87.5% in the control group, which was significantly higher in the ADP/BPO and the BPO group compared with the control group (p=0.0006, p=0.0006). The number of inflammatory acne lesions, a secondary endpoint, was significantly lower in both the ADP/BPO and BPO groups compared with the control group at 24 weeks (p=0.0016, p=0.0482). At 24 weeks, the ADP/BPO and BPO groups showed a significant improvement in the rate of change in atrophic scar count compared to baseline (p=0.0004, p<0.0001). For the scar formation, the rate of change in 3D image analysis parameters was not significantly changed in the ADP/BPO and BPO group compared to the baseline at 24 weeks, but was significant in the control group. Side effects occurred in 3 patients (7.5%) in the ADP/BPO group and none in the BPO group. Conclusion: The maintenance therapy with anti-acne drugs is useful for Japanese patients with acne vulgaris and is expected to reduce the number of atrophic scars and prevent scar deterioration." @default.
- W4366185383 created "2023-04-19" @default.
- W4366185383 creator A5074916856 @default.
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- W4366185383 date "2023-05-01" @default.
- W4366185383 modified "2023-09-28" @default.
- W4366185383 title "1118 Examination of usefulness of maintenance therapy with adapalene 0.1%/benzoyl peroxide 2.5% gel and benzoyl peroxide 2.5% gel for acne vulgaris and evaluation of atrophic acne scars using 3D image analysis" @default.
- W4366185383 doi "https://doi.org/10.1016/j.jid.2023.03.1130" @default.
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