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- W4366185792 abstract "Rosacea is a common chronic inflammatory facial disorder. Reactive oxygen species (ROS) have a key role in the pathogenesis of rosacea. In this study, the antioxidant and anti-inflammatory effects of bilirubin-based nanoparticles (BRNPs) were investigated in the LL-37-induced rosacea-like mouse model. Effects of BRNPs on rosacea-like skin inflammation and ROS level of the skin were determined using histological analysis. The expression of genes encoding rosacea-associated cytokines and chemokines was assessed and the molecular mechanisms of BRNPs against rosacea were investigated using RNA sequencing (RNAseq) analysis. Our study reveals that BRNPs significantly alleviated LL-37-induced inflammatory manifestation in the rosacea mouse model and reduced the expression of pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and chemokines (C-X-C motif chemokine ligand 8 [CXCL8] and CXCL10). Moreover, BRNPs preferentially localized at the inflammatory skin lesion, decreased the level of ROS in the skin, and ameliorated the vascular endothelial growth factor expression and vascular changes in the skin induced by LL-37. Furthermore, our findings provide a mechanism for the efficacy of BRNPs in this experimental model and support BRNPs as a potential therapeutic option for rosacea and other related inflammatory skin disorders." @default.
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- W4366185792 date "2023-05-01" @default.
- W4366185792 modified "2023-10-18" @default.
- W4366185792 title "1337 Bilirubin nanomedicine alleviates inflammation and angiogenesis in a rosacea mouse model" @default.
- W4366185792 doi "https://doi.org/10.1016/j.jid.2023.03.1353" @default.
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