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- W4366186058 abstract "In the human skin, melanocytes are present in the epidermis and hair follicles. In addition to melanin, melanopsin is found in melanocytes. Melanopsin absorbs visible light with maximally sensitive to blue light. Melanopsin in retinal ganglion cells are involved in the regulation of circadian rhythm via a melanopsin/transient receptor potential canonical (TRPC) channel axis. We hypothesized that after blue LED lighting on the skin, the melanopsin/TRPC channel axis in the epidermal melanocytes plays significant roles in modulating the pathophysiological reactions both in the brain and skin. We selected two closely related hairless mouse strain, i.e., male Crl:SKH1 (nonpigmented, SKH1) and SKH2/J-Hrrh/Hrrh (pigmented, SKH2), to simulate human epidermis for blue LED lighting experiments. After receiving blue LED light, our important results of SKH2 mice included: (1) Functional MRI revealed that epidermal melanocytes might play a significant role in the modulating of brain connectivity especially hippocampus; (2) Alterations of circadian proteins CLOCK and Per2 expression could be found in the hippocampus; (3) Downregulation of circadian protein Cry1 expression and an increase in Bmail1 expression in the epidermis of SKH2 mice as compared to SKH1 mice. The interactions and pathomechanisms between epidermal melanocytes and brain functions after blue LED lighting will be discussed." @default.
- W4366186058 created "2023-04-19" @default.
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- W4366186058 date "2023-05-01" @default.
- W4366186058 modified "2023-09-26" @default.
- W4366186058 title "1257 Effects and mechanisms of blue LED lighting on brain functions through epidermal melanocytes of mice" @default.
- W4366186058 doi "https://doi.org/10.1016/j.jid.2023.03.1271" @default.
- W4366186058 hasPublicationYear "2023" @default.
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