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- W4366186070 abstract "Artemisia annua is an annual herb used in TCM. We previously demonstrated that a novel oil extract from A. annua powder called artemisia naphtha (AN) possesses several skin benefitting properties. Moreover, 1% AN gel was shown to reduce acne blemishes and the appearance of redness clinically in humans. With AN oil demonstrating an effective activity profile for those with sensitive and/or acne prone skin, we sought to further examine its activity in several in vivo models. Specifically, AN oil was tested in a: 1) Carbotriol-induced atopic dermatitis (AD) model, 2) Imiquimod-induced psoriasis model, 3) C. acnes injected model and 4) UV-induced skin barrier damage model. Results show AN oil effectively reduces mouse ear thickness and TSLP, IL-1β, IL-4, IL-5 and IL-6 in the AD model. In the psoriasis model, AN oil significantly relieves skin lesions, decrease PASI scores and for both the psoriasis and acne mouse models, AN oil inhibits IL-1β, TNFα, and IL-6 production. In the UV mouse model, AN oil improves skin moisture index and reduces S. aureus, suggesting enhancement of skin barrier function and a positive influence on the skin microbiome. To further characterize the potential benefits of AN oil on the skin microbiome, a clinical study was performed (n=31, 4 wk) on subjects with sensitive skin applying 0.1% AN oil daily. Utilizing 16s rRNA sequencing, results show after 7 days there was a significant increase in the α diversity of bacterial community. Moreover, several specific strains were effected including increasing F. prausnitzii, which has been shown to be decreased in AD and psoriasis subjects. Conversely, A. junii was lowered after applying AN oil, an important pathogen when the immune mechanism is impaired and broad-spectrum antibiotics are constantly used, thus reducing it could be beneficial. Altogether, AN oil demonstrates a diverse activity profile that when applied topically may be effective against several different skin conditions." @default.
- W4366186070 created "2023-04-19" @default.
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- W4366186070 date "2023-05-01" @default.
- W4366186070 modified "2023-09-27" @default.
- W4366186070 title "1003 Artemisia naphtha (AN): A novel oil extract effective in several in vivo skin models and modulates the skin microbiome in human subjects" @default.
- W4366186070 doi "https://doi.org/10.1016/j.jid.2023.03.1014" @default.
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