Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366190430> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4366190430 endingPage "S156" @default.
- W4366190430 startingPage "S156" @default.
- W4366190430 abstract "Recently, obesity has been known to be associated with psoriasis: obesity has negative effects on the prevalence, severity, and treatment response of psoriasis. However, systemic inflammation other than skin has not been thoroughly investigated in obesity-associated psoriasis. We induced obesity by HFD and psoriasis by imiquimod application in mice. Changes in body weight and fat mass was evaluated by mass spectrometry. Expression of inflammatory cytokines and lesional skin and gonadal fat tissue was evaluated with RT-PCR. With imiquimod application, there was a noticeable decrease in body weight and fat, which was significantly worse in obese than lean mice. Subcutaneous fat layer was significantly thinner in imiquimod-treated obese mice compared to control obese mice, and the expression of inflammatory cytokines, including IL-1b, was higher in the gonadal fat tissue of imiquimod-treated obese mice. In lesional skin, expression of inflammatory cytokines critical in psoriasis pathogenesis, such as Il-17a, IL-23, and IL-22 were significantly increased in obese psoriasis mice than lean psoriasis mice or obese control mice, consistent with the previous findings of obesity-induced aggravation of psoriasis inflammation.We found that imiquimod exaggerates obesity-associated adipose tissue inflammation in murine psoriasis model, suggesting that systemic inflammation, such as that in adipose tissue, needs to be considered when evaluating imiquimod-induced psoriatic inflammation in mice." @default.
- W4366190430 created "2023-04-19" @default.
- W4366190430 creator A5034518994 @default.
- W4366190430 creator A5079398365 @default.
- W4366190430 creator A5080215023 @default.
- W4366190430 date "2023-05-01" @default.
- W4366190430 modified "2023-09-28" @default.
- W4366190430 title "907 Imiquimod exacerbates the adipose tissue inflammation In murine psoriasis model associated with obesity" @default.
- W4366190430 doi "https://doi.org/10.1016/j.jid.2023.03.918" @default.
- W4366190430 hasPublicationYear "2023" @default.
- W4366190430 type Work @default.
- W4366190430 citedByCount "0" @default.
- W4366190430 crossrefType "journal-article" @default.
- W4366190430 hasAuthorship W4366190430A5034518994 @default.
- W4366190430 hasAuthorship W4366190430A5079398365 @default.
- W4366190430 hasAuthorship W4366190430A5080215023 @default.
- W4366190430 hasBestOaLocation W43661904301 @default.
- W4366190430 hasConcept C126322002 @default.
- W4366190430 hasConcept C134018914 @default.
- W4366190430 hasConcept C164027704 @default.
- W4366190430 hasConcept C171089720 @default.
- W4366190430 hasConcept C203014093 @default.
- W4366190430 hasConcept C2776252253 @default.
- W4366190430 hasConcept C2776914184 @default.
- W4366190430 hasConcept C2779112978 @default.
- W4366190430 hasConcept C2780564577 @default.
- W4366190430 hasConcept C511355011 @default.
- W4366190430 hasConcept C71924100 @default.
- W4366190430 hasConceptScore W4366190430C126322002 @default.
- W4366190430 hasConceptScore W4366190430C134018914 @default.
- W4366190430 hasConceptScore W4366190430C164027704 @default.
- W4366190430 hasConceptScore W4366190430C171089720 @default.
- W4366190430 hasConceptScore W4366190430C203014093 @default.
- W4366190430 hasConceptScore W4366190430C2776252253 @default.
- W4366190430 hasConceptScore W4366190430C2776914184 @default.
- W4366190430 hasConceptScore W4366190430C2779112978 @default.
- W4366190430 hasConceptScore W4366190430C2780564577 @default.
- W4366190430 hasConceptScore W4366190430C511355011 @default.
- W4366190430 hasConceptScore W4366190430C71924100 @default.
- W4366190430 hasIssue "5" @default.
- W4366190430 hasLocation W43661904301 @default.
- W4366190430 hasOpenAccess W4366190430 @default.
- W4366190430 hasPrimaryLocation W43661904301 @default.
- W4366190430 hasRelatedWork W1964688190 @default.
- W4366190430 hasRelatedWork W2049045125 @default.
- W4366190430 hasRelatedWork W2119264823 @default.
- W4366190430 hasRelatedWork W2167541966 @default.
- W4366190430 hasRelatedWork W2313033156 @default.
- W4366190430 hasRelatedWork W2914996562 @default.
- W4366190430 hasRelatedWork W2949430364 @default.
- W4366190430 hasRelatedWork W3088195825 @default.
- W4366190430 hasRelatedWork W4214871516 @default.
- W4366190430 hasRelatedWork W4319296873 @default.
- W4366190430 hasVolume "143" @default.
- W4366190430 isParatext "false" @default.
- W4366190430 isRetracted "false" @default.
- W4366190430 workType "article" @default.