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- W4366190458 abstract "Background: Thymus and activation-regulated chemokine (TARC) is designated as a T-helper 2-type (Th2) chemokine and it has been reported that its serum level in patients with psoriasis vulgaris (PsV) was comparable with those in healthy controls. Previously we revealed that the serum TARC level was significantly higher in patients with generalized pustular psoriasis (GPP) than in those with PsV and those with psoriatic arthritis (PsA). However, the cells which produce TARC in GPP patients have never been identified. Objectives: To identify producers of TARC in GPP patients. Methods: Immunostaining with an anti-TARC antibody was performed on the skin of patients with GPP, PsV, or atopic dermatitis (AD) as a positive controls and healthy controls as a negative control. In addition, serum levels including Th2-related cytokines were measured by LEGENDplex® in patients with PsV, PsA, or GPP, and healthy controls. Results: Immunostaining revealed that TARC-positive cells were observed in the epidermis, especially basal cell layer and suprabasal layer, but that there were few TARC-positive cells in the dermis of the skin obtained from all six GPP patients, which was different from the results of the skin from AD patients. No increases in the serum levels of interleukin (IL)-4, IL-5, or IL-13 were observed in GPP patients compared with those with PsV or PsA, and healthy controls. The serum IL-9 level was significantly higher in GPP patients than in those with PsA and healthy controls. The serum interferon-γ level, which is also known to drive keratinocytes to produce TARC in vitro, was not elevated in GPP patients. Conclusion: Our study demonstrated that keratinocytes produced TARC in GPP patients, although the serum levels of Th2 cytokines were not elevated except IL-9. Further investigation is needed to elucidate the association of TARC production with IL-9 and to identify unknown factors to drive keratinocytes to produce TARC in GPP." @default.
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- W4366190458 date "2023-05-01" @default.
- W4366190458 modified "2023-09-28" @default.
- W4366190458 title "920 Epidermal keratinocytes produce thymus and activation-regulated chemokine in patients with generalized pustular psoriasis" @default.
- W4366190458 doi "https://doi.org/10.1016/j.jid.2023.03.931" @default.
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