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- W4366193776 abstract "Neurons show remarkable morphological diversity facilitated by transcriptional regulation during development and fitting with their connectivity and function. Second messenger pathways mediated by cyclic 3',5' adenosine or guanosine monophosphate (cAMP or cGMP) may serve to integrate extrinsic signals and regulate branching and growth of neurites. We investigated the regulation of cGMP signaling in neuronal morphogenesis in Drosophila somatosensory neurons and found cell type-specificity in expression of the enzyme soluble guanylate cyclase (sGC) in different sensory neuron classes. sGC is responsible for the production of cGMP in response to the diffusible free radical messenger nitric oxide (NO) such that different levels of sGC impart cell type-specific sensitivity to NO. Supporting a role for the NO-cGMP pathway in neuronal morphogenesis, we find that knockout of sGC or nitric oxide synthase (NOS) impacts the morphology of multidendritic proprioceptors. The homeodomain transcription factor Cut shows different levels of expression in different somatosensory neuron types and we find that Cut regulates the level of cGMP signaling via repression of sGC expression. Thus, transcription factor levels contribute to cell type diversification by regulating levels of a signaling pathway to mediate somatosensory neuron morphogenesis." @default.
- W4366193776 created "2023-04-19" @default.
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- W4366193776 date "2023-04-15" @default.
- W4366193776 modified "2023-09-28" @default.
- W4366193776 title "A cell-type-specific nitric oxide-cGMP pathway regulates proprioceptor morphology" @default.
- W4366193776 doi "https://doi.org/10.1101/2023.04.14.536921" @default.
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