Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366199883> ?p ?o ?g. }
- W4366199883 abstract "The spiking activity of neocortical neurons exhibits a striking level of variability, even when these networks are driven by identical stimuli. The approximately Poisson firing of neurons has led to the hypothesis that these neural networks operate in the asynchronous state. In the asynchronous state neurons fire independently from one another, so that the probability that a neuron experience synchronous synaptic inputs is exceedingly low. While the models of asynchronous neurons lead to observed spiking variability, it is not clear whether the asynchronous state can also account for the level of subthreshold membrane potential variability. We propose a new analytical framework to rigorously quantify the subthreshold variability of a single conductance-based neuron in response to synaptic inputs with prescribed degrees of synchrony. Technically we leverage the theory of exchangeability to model input synchrony via jump-process-based synaptic drives; we then perform a moment analysis of the stationary response of a neuronal model with all-or-none conductances that neglects post-spiking reset. As a result, we produce exact, interpretable closed forms for the first two stationary moments of the membrane voltage, with explicit dependence on the input synaptic numbers, strengths, and synchrony. For biophysically relevant parameters, we find that the asynchronous regime only yields realistic subthreshold variability (voltage variance $simeq 4-9mathrm{mV^2}$) when driven by a restricted number of large synapses, compatible with strong thalamic drive. By contrast, we find that achieving realistic subthreshold variability with dense cortico-cortical inputs requires including weak but nonzero input synchrony, consistent with measured pairwise spiking correlations." @default.
- W4366199883 created "2023-04-19" @default.
- W4366199883 creator A5001023499 @default.
- W4366199883 creator A5004043467 @default.
- W4366199883 creator A5040241674 @default.
- W4366199883 creator A5075242899 @default.
- W4366199883 creator A5085643760 @default.
- W4366199883 date "2023-04-17" @default.
- W4366199883 modified "2023-09-27" @default.
- W4366199883 title "Exact analysis of the subthreshold variability for conductance-based neuronal models with synchronous synaptic inputs" @default.
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