Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366201162> ?p ?o ?g. }
- W4366201162 abstract "Abstract Anti-tumor drug resistance is a challenge for human triple-negative breast cancer treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote triple-negative breast cancer cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin β4. Integrin β4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer. These results indicate that the Integrin β4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in triple-negative breast cancer." @default.
- W4366201162 created "2023-04-19" @default.
- W4366201162 creator A5002752290 @default.
- W4366201162 creator A5010352694 @default.
- W4366201162 creator A5033684035 @default.
- W4366201162 creator A5037634210 @default.
- W4366201162 creator A5038892722 @default.
- W4366201162 creator A5041351237 @default.
- W4366201162 creator A5047917101 @default.
- W4366201162 creator A5054934190 @default.
- W4366201162 creator A5066099693 @default.
- W4366201162 creator A5077932143 @default.
- W4366201162 creator A5082664273 @default.
- W4366201162 date "2023-04-17" @default.
- W4366201162 modified "2023-09-23" @default.
- W4366201162 title "Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1" @default.
- W4366201162 cites W1568345151 @default.
- W4366201162 cites W1674293076 @default.
- W4366201162 cites W1966834115 @default.
- W4366201162 cites W1971768045 @default.
- W4366201162 cites W1971811485 @default.
- W4366201162 cites W1985643113 @default.
- W4366201162 cites W2028236537 @default.
- W4366201162 cites W2033346155 @default.
- W4366201162 cites W2050142910 @default.
- W4366201162 cites W2053785734 @default.
- W4366201162 cites W2068626866 @default.
- W4366201162 cites W2069738597 @default.
- W4366201162 cites W2078334282 @default.
- W4366201162 cites W2080319486 @default.
- W4366201162 cites W2092629648 @default.
- W4366201162 cites W2111065172 @default.
- W4366201162 cites W2124816232 @default.
- W4366201162 cites W2140056178 @default.
- W4366201162 cites W2140955917 @default.
- W4366201162 cites W2143612979 @default.
- W4366201162 cites W2149747710 @default.
- W4366201162 cites W2160157675 @default.
- W4366201162 cites W2254906934 @default.
- W4366201162 cites W2325140501 @default.
- W4366201162 cites W2514443087 @default.
- W4366201162 cites W2593940162 @default.
- W4366201162 cites W2605064251 @default.
- W4366201162 cites W2766441357 @default.
- W4366201162 cites W2768583786 @default.
- W4366201162 cites W2788415549 @default.
- W4366201162 cites W2800852522 @default.
- W4366201162 cites W2887861777 @default.
- W4366201162 cites W2887985198 @default.
- W4366201162 cites W2889646458 @default.
- W4366201162 cites W2936232559 @default.
- W4366201162 cites W2956019456 @default.
- W4366201162 cites W2968820602 @default.
- W4366201162 cites W2976114653 @default.
- W4366201162 cites W2985254123 @default.
- W4366201162 cites W2995510656 @default.
- W4366201162 cites W3010871483 @default.
- W4366201162 cites W3017015088 @default.
- W4366201162 cites W3024764930 @default.
- W4366201162 cites W3035905703 @default.
- W4366201162 cites W3092655545 @default.
- W4366201162 cites W3098089549 @default.
- W4366201162 cites W3188792319 @default.
- W4366201162 cites W4226164056 @default.
- W4366201162 cites W4281622500 @default.
- W4366201162 doi "https://doi.org/10.1101/2023.04.17.537130" @default.
- W4366201162 hasPublicationYear "2023" @default.
- W4366201162 type Work @default.
- W4366201162 citedByCount "0" @default.
- W4366201162 crossrefType "posted-content" @default.
- W4366201162 hasAuthorship W4366201162A5002752290 @default.
- W4366201162 hasAuthorship W4366201162A5010352694 @default.
- W4366201162 hasAuthorship W4366201162A5033684035 @default.
- W4366201162 hasAuthorship W4366201162A5037634210 @default.
- W4366201162 hasAuthorship W4366201162A5038892722 @default.
- W4366201162 hasAuthorship W4366201162A5041351237 @default.
- W4366201162 hasAuthorship W4366201162A5047917101 @default.
- W4366201162 hasAuthorship W4366201162A5054934190 @default.
- W4366201162 hasAuthorship W4366201162A5066099693 @default.
- W4366201162 hasAuthorship W4366201162A5077932143 @default.
- W4366201162 hasAuthorship W4366201162A5082664273 @default.
- W4366201162 hasBestOaLocation W43662011621 @default.
- W4366201162 hasConcept C114851261 @default.
- W4366201162 hasConcept C121608353 @default.
- W4366201162 hasConcept C126322002 @default.
- W4366201162 hasConcept C142669718 @default.
- W4366201162 hasConcept C143425029 @default.
- W4366201162 hasConcept C1491633281 @default.
- W4366201162 hasConcept C2779560292 @default.
- W4366201162 hasConcept C2779717556 @default.
- W4366201162 hasConcept C2780110267 @default.
- W4366201162 hasConcept C502942594 @default.
- W4366201162 hasConcept C530470458 @default.
- W4366201162 hasConcept C54355233 @default.
- W4366201162 hasConcept C552990157 @default.
- W4366201162 hasConcept C55493867 @default.
- W4366201162 hasConcept C62478195 @default.
- W4366201162 hasConcept C71924100 @default.
- W4366201162 hasConcept C86803240 @default.
- W4366201162 hasConcept C95444343 @default.