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- W4366201816 abstract "Abstract CD8 + T cells play a central role in antitumor immune responses. Epigenetic gene regulation is essential to acquire the effector function of CD8 + T cells. However, the role of Utx , a demethylase of histone H3K27, in antitumor immunity remains unclear. In this study, we examined the roles of Utx in effector CD8 + T‐cell differentiation and the antitumor immune response. In a murine tumor‐bearing model, an increased tumor size and decreased survival rate were observed in T‐cell‐specific Utx KO ( Utx KO) mice compared with wild‐type (WT) mice. The number of CD8 + T cells in tumor‐infiltrating lymphocytes (TILs) was significantly decreased in Utx KO mice. We found that the acquisition of effector function was delayed and attenuated in Utx KO CD8 + T cells. RNA sequencing revealed that the expression of effector signature genes was decreased in Utx KO effector CD8 + T cells, while the expression of naïve or memory signature genes was increased. Furthermore, the expression of Cxcr3, which is required for the migration of effector CD8 + T cells to tumor sites, was substantially decreased in Utx KO CD8 + T cells. These findings suggest that Utx promotes CD8 + T‐cell‐dependent antitumor immune responses partially through epigenetic regulation of the effector function." @default.
- W4366201816 created "2023-04-19" @default.
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- W4366201816 date "2023-04-17" @default.
- W4366201816 modified "2023-10-15" @default.
- W4366201816 title "The histone demethylase Utx controls <scp>CD8</scp><sup>+</sup> T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function" @default.
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- W4366201816 doi "https://doi.org/10.1111/cas.15814" @default.
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