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- W4366202261 abstract "MicroRNA (miR)-145 is enriched in the follicular granulosa cells (GCs) of 3-week-old mice. Downregulating miR-145 inhibits the proliferation and differentiation of GCs and induces evident changes in their cytoskeleton. In this study, we examined how miR-145 induces cytoskeletal changes in mouse GCs and its potential mechanism in regulating GC steroidogenesis. We found that actin related protein 2/3 complex subunit 5 (Arpc5) is a target of miR-145. The miR-145 antagomir increased ARPC5 expression but not β-ACTIN, β-TUBULIN, and PAXILLIN expression. Arpc5 overexpression inhibited GC proliferation, differentiation, and progesterone synthesis. Furthermore, the expression of progesterone synthesis-associated enzymes was downregulated in the Arpc5 overexpression group, and the GC cytoskeleton exhibited evident changes. We conclude that Arpc5, a new target of miR-145, regulates primary GC proliferation and progesterone production by regulating the cytoskeleton remodeling." @default.
- W4366202261 created "2023-04-19" @default.
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- W4366202261 date "2023-01-01" @default.
- W4366202261 modified "2023-09-26" @default.
- W4366202261 title "<i>MiR-145</i> regulates steroidogenesis in mouse primary granulosa cells by targeting <i>Arpc5</i> and subsequent cytoskeleton remodeling" @default.
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- W4366202261 doi "https://doi.org/10.1262/jrd.2022-137" @default.
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