FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366202488> ?p ?o ?g. }

• W4366202488 abstract "Abstract Hypereosinophilia (HE) can be caused by a wide variety of non-hematologic (secondary or reactive) and hematologic (primary, clonal) disorders. Diagnosing hypereosinophilia/hypereosinophilic syndrome (HE/HES) is challenging due to the complex nature of disease manifestations and numerous underlying etiologies. Knowing that only rare cases are clonal, it is wise to rule out reactive conditions and proceed with molecular and other advanced tools. The exclusion of secondary causes needs a detailed clinical evaluation followed by a wide range of serological and imaging investigations. Once reactive eosinophilia has been ruled out, the diagnosis of primary HE/HES is made using a combination of morphologic examination of the blood and bone marrow, conventional cytogenetics, fluorescent in situ hybridization, flow-cytometry, and T-cell clonality evaluation to look for histopathologic or clonal evidence of an underlying hematological disorder. The accurate diagnosis of clonal eosinophilia-causing myeloid and lymphoid neoplasms and the identification of numerous gene rearrangements significantly enhance patient outcomes, because a proportion of these patients (such as PDGFRA and PDGFRB rearrangements) responds well to tyrosine kinase inhibitors. Considering the complex etiopathologies, the cost of testing, and the time involved, the workup needs to be tailored according to the urgency of the situation and the resources available. In urgent situations with organ damage, it is crucial to initiate appropriate management without waiting for the results of investigations. In contrast, in a resource-limited situation, it is acceptable to employ step-by-step rather than comprehensive testing to rule out the most common causes first. Here, we discuss various laboratory investigations employed in diagnosing HE/HES, highlighting their importance in different situations." @default.
• W4366202488 created "2023-04-19" @default.
• W4366202488 creator A5064098843 @default.
• W4366202488 creator A5080464306 @default.
• W4366202488 date "2023-04-17" @default.
• W4366202488 modified "2023-10-01" @default.
• W4366202488 title "Laboratory workup of Hypereosinophilia" @default.
• W4366202488 cites W1980046230 @default.
• W4366202488 cites W2001426718 @default.
• W4366202488 cites W2003981674 @default.
• W4366202488 cites W2012952884 @default.
• W4366202488 cites W2050068982 @default.
• W4366202488 cites W2053597373 @default.
• W4366202488 cites W2053916612 @default.
• W4366202488 cites W2063518972 @default.
• W4366202488 cites W2066724445 @default.
• W4366202488 cites W2073301684 @default.
• W4366202488 cites W2080703172 @default.
• W4366202488 cites W2096034121 @default.
• W4366202488 cites W2114583539 @default.
• W4366202488 cites W2116629370 @default.
• W4366202488 cites W2119490410 @default.
• W4366202488 cites W2125324659 @default.
• W4366202488 cites W2132511638 @default.
• W4366202488 cites W2147896253 @default.
• W4366202488 cites W2354069820 @default.
• W4366202488 cites W2404987423 @default.
• W4366202488 cites W2514806122 @default.
• W4366202488 cites W2582394251 @default.
• W4366202488 cites W2615682251 @default.
• W4366202488 cites W2773163141 @default.
• W4366202488 cites W2810160639 @default.
• W4366202488 cites W2888838889 @default.
• W4366202488 cites W2963891116 @default.
• W4366202488 cites W2994185748 @default.
• W4366202488 cites W2995020090 @default.
• W4366202488 cites W2996680638 @default.
• W4366202488 cites W3011765309 @default.
• W4366202488 cites W3014314694 @default.
• W4366202488 cites W3048323385 @default.
• W4366202488 cites W3081702597 @default.
• W4366202488 cites W3082526167 @default.
• W4366202488 cites W3131613691 @default.
• W4366202488 cites W3136310982 @default.
• W4366202488 cites W3199272359 @default.
• W4366202488 cites W3201864442 @default.
• W4366202488 cites W3215454286 @default.
• W4366202488 cites W4210713317 @default.
• W4366202488 cites W4283271244 @default.
• W4366202488 cites W4288045645 @default.
• W4366202488 doi "https://doi.org/10.1055/s-0043-1761261" @default.
• W4366202488 hasPublicationYear "2023" @default.
• W4366202488 type Work @default.
• W4366202488 citedByCount "0" @default.
• W4366202488 crossrefType "journal-article" @default.
• W4366202488 hasAuthorship W4366202488A5064098843 @default.
• W4366202488 hasAuthorship W4366202488A5080464306 @default.
• W4366202488 hasBestOaLocation W43662024881 @default.
• W4366202488 hasConcept C104317684 @default.
• W4366202488 hasConcept C142724271 @default.
• W4366202488 hasConcept C203014093 @default.
• W4366202488 hasConcept C2777129736 @default.
• W4366202488 hasConcept C2777621362 @default.
• W4366202488 hasConcept C2778219007 @default.
• W4366202488 hasConcept C2779084869 @default.
• W4366202488 hasConcept C2779282312 @default.
• W4366202488 hasConcept C2779758542 @default.
• W4366202488 hasConcept C2780007613 @default.
• W4366202488 hasConcept C55493867 @default.
• W4366202488 hasConcept C71924100 @default.
• W4366202488 hasConcept C78221974 @default.
• W4366202488 hasConcept C86803240 @default.
• W4366202488 hasConceptScore W4366202488C104317684 @default.
• W4366202488 hasConceptScore W4366202488C142724271 @default.
• W4366202488 hasConceptScore W4366202488C203014093 @default.
• W4366202488 hasConceptScore W4366202488C2777129736 @default.
• W4366202488 hasConceptScore W4366202488C2777621362 @default.
• W4366202488 hasConceptScore W4366202488C2778219007 @default.
• W4366202488 hasConceptScore W4366202488C2779084869 @default.
• W4366202488 hasConceptScore W4366202488C2779282312 @default.
• W4366202488 hasConceptScore W4366202488C2779758542 @default.
• W4366202488 hasConceptScore W4366202488C2780007613 @default.
• W4366202488 hasConceptScore W4366202488C55493867 @default.
• W4366202488 hasConceptScore W4366202488C71924100 @default.
• W4366202488 hasConceptScore W4366202488C78221974 @default.
• W4366202488 hasConceptScore W4366202488C86803240 @default.
• W4366202488 hasLocation W43662024881 @default.
• W4366202488 hasOpenAccess W4366202488 @default.
• W4366202488 hasPrimaryLocation W43662024881 @default.
• W4366202488 hasRelatedWork W1995016923 @default.
• W4366202488 hasRelatedWork W2032288846 @default.
• W4366202488 hasRelatedWork W2060444546 @default.
• W4366202488 hasRelatedWork W2061414204 @default.
• W4366202488 hasRelatedWork W2072982356 @default.
• W4366202488 hasRelatedWork W2145566417 @default.
• W4366202488 hasRelatedWork W2413007421 @default.
• W4366202488 hasRelatedWork W2917256218 @default.
• W4366202488 hasRelatedWork W2917388072 @default.
• W4366202488 hasRelatedWork W3021808706 @default.
• W4366202488 isParatext "false" @default.

• next