FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366208730> ?p ?o ?g. }

• W4366208730 endingPage "1169" @default.
• W4366208730 startingPage "1169" @default.
• W4366208730 abstract "Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double-stranded DNA by a homologous single-stranded DNA (ssDNA) covered by RAD51. Thus, RAD51 plays a prime role in HR through this canonical catalytic strand invasion/exchange activity. The mutations in many HR genes cause oncogenesis. Surprisingly, despite its central role in HR, the invalidation of RAD51 is not classified as being cancer prone, constituting the RAD51 paradox. This suggests that RAD51 exercises other noncanonical roles that are independent of its catalytic strand invasion/exchange function. For example, the binding of RAD51 on ssDNA prevents nonconservative mutagenic DNA repair, which is independent of its strand exchange activity but relies on its ssDNA occupancy. At the arrested replication forks, RAD51 plays several noncanonical roles in the formation, protection, and management of fork reversal, allowing for the resumption of replication. RAD51 also exhibits noncanonical roles in RNA-mediated processes. Finally, RAD51 pathogenic variants have been described in the congenital mirror movement syndrome, revealing an unexpected role in brain development. In this review, we present and discuss the different noncanonical roles of RAD51, whose presence does not automatically result in an HR event, revealing the multiple faces of this prominent actor in genomic plasticity." @default.
• W4366208730 created "2023-04-19" @default.
• W4366208730 creator A5018470906 @default.
• W4366208730 creator A5035343602 @default.
• W4366208730 creator A5046374543 @default.
• W4366208730 creator A5046397498 @default.
• W4366208730 creator A5087457979 @default.
• W4366208730 date "2023-04-15" @default.
• W4366208730 modified "2023-10-18" @default.
• W4366208730 title "Noncanonical Roles of RAD51" @default.
• W4366208730 cites W1531540594 @default.
• W4366208730 cites W1533244785 @default.
• W4366208730 cites W1538419182 @default.
• W4366208730 cites W1831071073 @default.
• W4366208730 cites W1970578083 @default.
• W4366208730 cites W1976867806 @default.
• W4366208730 cites W1980636468 @default.
• W4366208730 cites W1983976485 @default.
• W4366208730 cites W1987086578 @default.
• W4366208730 cites W1988922095 @default.
• W4366208730 cites W1989491127 @default.
• W4366208730 cites W1995708463 @default.
• W4366208730 cites W1998727638 @default.
• W4366208730 cites W2001401425 @default.
• W4366208730 cites W2003685320 @default.
• W4366208730 cites W2004125597 @default.
• W4366208730 cites W2004867792 @default.
• W4366208730 cites W2006299554 @default.
• W4366208730 cites W2009851230 @default.
• W4366208730 cites W2014091491 @default.
• W4366208730 cites W2019642759 @default.
• W4366208730 cites W2021881561 @default.
• W4366208730 cites W2022972203 @default.
• W4366208730 cites W2034252391 @default.
• W4366208730 cites W2036990153 @default.
• W4366208730 cites W2041103655 @default.
• W4366208730 cites W2045506022 @default.
• W4366208730 cites W2045757858 @default.
• W4366208730 cites W2046066638 @default.
• W4366208730 cites W2049689768 @default.
• W4366208730 cites W2056406429 @default.
• W4366208730 cites W2061196115 @default.
• W4366208730 cites W2062739292 @default.
• W4366208730 cites W2064965689 @default.
• W4366208730 cites W2073204556 @default.
• W4366208730 cites W2075523355 @default.
• W4366208730 cites W2077423161 @default.
• W4366208730 cites W2078403259 @default.
• W4366208730 cites W2079235299 @default.
• W4366208730 cites W2089191852 @default.
• W4366208730 cites W2091219829 @default.
• W4366208730 cites W2104003823 @default.
• W4366208730 cites W2104584181 @default.
• W4366208730 cites W2110143309 @default.
• W4366208730 cites W2115100537 @default.
• W4366208730 cites W2116468279 @default.
• W4366208730 cites W2117692326 @default.
• W4366208730 cites W2122843169 @default.
• W4366208730 cites W2125433175 @default.
• W4366208730 cites W2125644182 @default.
• W4366208730 cites W2128824335 @default.
• W4366208730 cites W2138034994 @default.
• W4366208730 cites W2138494428 @default.
• W4366208730 cites W2138905898 @default.
• W4366208730 cites W2141599203 @default.
• W4366208730 cites W2143157366 @default.
• W4366208730 cites W2150773709 @default.
• W4366208730 cites W2153105873 @default.
• W4366208730 cites W2154968223 @default.
• W4366208730 cites W2165529204 @default.
• W4366208730 cites W2168204901 @default.
• W4366208730 cites W2169983032 @default.
• W4366208730 cites W2173561323 @default.
• W4366208730 cites W2185659123 @default.
• W4366208730 cites W2218955305 @default.
• W4366208730 cites W2269805131 @default.
• W4366208730 cites W2321915429 @default.
• W4366208730 cites W2323926705 @default.
• W4366208730 cites W2332948343 @default.
• W4366208730 cites W2344125613 @default.
• W4366208730 cites W2344657883 @default.
• W4366208730 cites W2346001051 @default.
• W4366208730 cites W2476568892 @default.
• W4366208730 cites W2513764101 @default.
• W4366208730 cites W2547767398 @default.
• W4366208730 cites W2569982054 @default.
• W4366208730 cites W2591957352 @default.
• W4366208730 cites W2623921962 @default.
• W4366208730 cites W2732024516 @default.
• W4366208730 cites W2737083047 @default.
• W4366208730 cites W2737658553 @default.
• W4366208730 cites W2742880086 @default.
• W4366208730 cites W2743954317 @default.
• W4366208730 cites W2757802282 @default.
• W4366208730 cites W2763248055 @default.
• W4366208730 cites W2768005938 @default.
• W4366208730 cites W2803857309 @default.
• W4366208730 cites W2895074278 @default.

• next