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• W4366208733 abstract "ABSTRACT Bacteriophages and bacteria are engaged in a constant arms race, continually evolving new molecular tools to survive one another. To protect their genomic DNA from restriction enzymes, the most common bacterial defence systems, double-stranded DNA phages have evolved complex modifications that affect all four bases. This study focuses on modifications at position 7 of guanines. Eight derivatives of 7-deazaguanines were identified, including four previously unknown ones: 2’-deoxy-7-(methylamino)methyl-7-deazaguanine (mdPreQ 1 ), 2’-deoxy-7-(formylamino)methyl-7-deazaguanine (fdPreQ 1 ), 2’-deoxy-7-deazaguanine (dDG), and 2’-deoxy-7-carboxy-7-deazaguanine (dCDG). These modifications are inserted in DNA by a guanine transglycosylase named DpdA. Three subfamilies of DpdA had been previously characterized: bDpdA, DpdA1, and DpdA2. Two additional subfamilies were identified in this work: DpdA3, which allows for complete replacement of the guanines, and DpdA4, which is specific to archaeal viruses. Transglycosylases have now been identified in all phages and viruses carrying 7-deazaguanine modifications, indicating that the insertion of these modifications is a post-replication event. Three enzymes were predicted to be involved in the biosynthesis of these newly identified DNA modifications: 7-carboxy-7-deazaguanine decarboxylase (DpdL), dPreQ 1 formyltransferase (DpdN), and dPreQ 1 methyltransferase (DpdM), which was experimentally validated and harbors a unique fold not previously observed for nucleic acid methylases." @default.
• W4366208733 created "2023-04-19" @default.
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• W4366208733 date "2023-04-16" @default.
• W4366208733 modified "2023-09-26" @default.
• W4366208733 title "Four additional natural 7-deazaguanine derivatives in phages and how to make them" @default.
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• W4366208733 doi "https://doi.org/10.1101/2023.04.13.536721" @default.
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