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- W4366235059 abstract "Abstract: Coagulation activation is associated with cancer progression and morbidity. Recently, mechanisms through which coagulation proteases drive the tumor microenvironment (TME) have been elucidated. This review aims to develop a new strategy dependent on the coagulation system for treating osteosarcoma (OS). We focused on tissue factor (TF), the main initiator of the extrinsic coagulant pathway, as a target for OS treatment. It was found that cell surface-TF, TF-positive extracellular vesicles, and TF-positive circulating tumor cells could drive progression, metastasis, and TME in carcinomas, including OS. Thus, targeting tumor-associated coagulation by focusing on TF, the principle catalyst of the extrinsic pathway, TF is a promising target for OS." @default.
- W4366235059 created "2023-04-20" @default.
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- W4366235059 date "2023-04-01" @default.
- W4366235059 modified "2023-10-06" @default.
- W4366235059 title "Advancing Tissue Factor-targeted Therapy for Osteosarcoma via Understanding its Role in the Tumor Microenvironment" @default.
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- W4366235059 doi "https://doi.org/10.2174/1381612829666230413094242" @default.
- W4366235059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37069710" @default.
- W4366235059 hasPublicationYear "2023" @default.
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