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• W4366235529 abstract "The ability to use past experience to effectively guide decision-making declines in older adulthood. Such declines have been theorized to emerge from either impairments of striatal reinforcement learning systems (RL) or impairments of recurrent networks in prefrontal and parietal cortex that support working memory (WM). Distinguishing between these hypotheses has been challenging because either RL or WM could be used to facilitate successful decision-making in typical laboratory tasks. Here we investigated the neurocomputational correlates of age-related decision-making deficits using an RL-WM task to disentangle these mechanisms, a computational model to quantify them, and magnetic resonance spectroscopy to link them to their molecular bases. Our results reveal that task performance is worse in older age, in a manner best explained by working memory deficits, as might be expected if cortical recurrent networks were unable to sustain persistent activity across multiple trials. Consistent with this, we show that older adults had lower levels of prefrontal glutamate, the excitatory neurotransmitter thought to support persistent activity, compared to younger adults. Individuals with the lowest prefrontal glutamate levels displayed the greatest impairments in working memory after controlling for other anatomical and metabolic factors. Together, our results suggest that lower levels of prefrontal glutamate may contribute to failures of working memory systems and impaired decision-making in older adulthood." @default.
• W4366235529 created "2023-04-20" @default.
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• W4366235529 date "2023-04-18" @default.
• W4366235529 modified "2023-09-29" @default.
• W4366235529 title "Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits" @default.
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• W4366235529 doi "https://doi.org/10.7554/elife.85243" @default.
• W4366235529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070807" @default.
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