Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366235785> ?p ?o ?g. }
- W4366235785 endingPage "21209" @default.
- W4366235785 startingPage "21198" @default.
- W4366235785 abstract "Identifying nitroreductase (NTR) with fluorescent techniques has become a research hotspot, due to its good sensitivity and selectivity toward the early-stage cancer diagnosis and monitoring. Herein, a host-guest reporter (NAQA⊂Zn-MPPB) is successfully achieved by encapsulating the NTR probe NAQA into a new NADH-functioned metal-organic cage Zn-MPPB, which makes the reporter for ultrafast detection of NTR within dozens of seconds in solution. The host-guest strategy fuses the Zn-MPPB and NAQA to form a pseudomolecule material, which changes the reaction process of NTR and NAQA from a double substrates mechanism to a single substrate one, and accelerates the reduction efficiency of NAQA. This advantage make the new host-guest reporter exhibit a linear relationship between emission changes and NTR concentration, and it shows better sensitively toward NTR than that of NAQA. Additionally, the positively charged water-soluble metal-organic cage can encapsulate NAQA in the cavity, promote it to dissolve in an aqueous environment, and facilitate their accumulation into tumor cells. As expected, such host-guest reporter displays a fast and high efficiently imaging capability toward NTR in tumor cells and tumor-bearing mice, and flow cytometry assay is conducted to corroborate the capability as well, implying the considerably potential of host-guest strategy for early tumor diagnosis and treatment." @default.
- W4366235785 created "2023-04-20" @default.
- W4366235785 creator A5052747732 @default.
- W4366235785 creator A5055693681 @default.
- W4366235785 creator A5058753442 @default.
- W4366235785 creator A5064299502 @default.
- W4366235785 creator A5065901443 @default.
- W4366235785 creator A5071798264 @default.
- W4366235785 creator A5079321464 @default.
- W4366235785 creator A5085152562 @default.
- W4366235785 date "2023-04-18" @default.
- W4366235785 modified "2023-10-12" @default.
- W4366235785 title "Supramolecular Host–Guest Strategy for the Accelerating Detection of Nitroreductase" @default.
- W4366235785 cites W2009465544 @default.
- W4366235785 cites W2068519010 @default.
- W4366235785 cites W2159203122 @default.
- W4366235785 cites W2515286124 @default.
- W4366235785 cites W2560717561 @default.
- W4366235785 cites W2567099032 @default.
- W4366235785 cites W2668542834 @default.
- W4366235785 cites W2766165445 @default.
- W4366235785 cites W2782999406 @default.
- W4366235785 cites W2887302536 @default.
- W4366235785 cites W2906405458 @default.
- W4366235785 cites W2909454831 @default.
- W4366235785 cites W2914422905 @default.
- W4366235785 cites W2918126453 @default.
- W4366235785 cites W2926888608 @default.
- W4366235785 cites W2944103495 @default.
- W4366235785 cites W2954421483 @default.
- W4366235785 cites W2955560122 @default.
- W4366235785 cites W2970405392 @default.
- W4366235785 cites W2972865283 @default.
- W4366235785 cites W2977772759 @default.
- W4366235785 cites W2977788202 @default.
- W4366235785 cites W2978992678 @default.
- W4366235785 cites W2998872044 @default.
- W4366235785 cites W3005052428 @default.
- W4366235785 cites W3005546842 @default.
- W4366235785 cites W3005861989 @default.
- W4366235785 cites W3007756421 @default.
- W4366235785 cites W3009721059 @default.
- W4366235785 cites W3011715566 @default.
- W4366235785 cites W3013959696 @default.
- W4366235785 cites W3016007013 @default.
- W4366235785 cites W3016476799 @default.
- W4366235785 cites W3016717889 @default.
- W4366235785 cites W3033694889 @default.
- W4366235785 cites W3041483557 @default.
- W4366235785 cites W3085166295 @default.
- W4366235785 cites W3086112561 @default.
- W4366235785 cites W3091817328 @default.
- W4366235785 cites W3093138023 @default.
- W4366235785 cites W3155422383 @default.
- W4366235785 cites W3160826957 @default.
- W4366235785 cites W3162020708 @default.
- W4366235785 cites W3171293133 @default.
- W4366235785 cites W3175424117 @default.
- W4366235785 cites W3183705430 @default.
- W4366235785 cites W3189075912 @default.
- W4366235785 cites W3194756115 @default.
- W4366235785 cites W4200176616 @default.
- W4366235785 cites W4200449903 @default.
- W4366235785 cites W4200587062 @default.
- W4366235785 cites W4206596679 @default.
- W4366235785 cites W4220803547 @default.
- W4366235785 cites W4294129121 @default.
- W4366235785 cites W4295094242 @default.
- W4366235785 cites W4306861695 @default.
- W4366235785 cites W4310777137 @default.
- W4366235785 doi "https://doi.org/10.1021/acsami.2c22851" @default.
- W4366235785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070853" @default.
- W4366235785 hasPublicationYear "2023" @default.
- W4366235785 type Work @default.
- W4366235785 citedByCount "0" @default.
- W4366235785 crossrefType "journal-article" @default.
- W4366235785 hasAuthorship W4366235785A5052747732 @default.
- W4366235785 hasAuthorship W4366235785A5055693681 @default.
- W4366235785 hasAuthorship W4366235785A5058753442 @default.
- W4366235785 hasAuthorship W4366235785A5064299502 @default.
- W4366235785 hasAuthorship W4366235785A5065901443 @default.
- W4366235785 hasAuthorship W4366235785A5071798264 @default.
- W4366235785 hasAuthorship W4366235785A5079321464 @default.
- W4366235785 hasAuthorship W4366235785A5085152562 @default.
- W4366235785 hasConcept C10390740 @default.
- W4366235785 hasConcept C121332964 @default.
- W4366235785 hasConcept C12554922 @default.
- W4366235785 hasConcept C126831891 @default.
- W4366235785 hasConcept C147789679 @default.
- W4366235785 hasConcept C153911025 @default.
- W4366235785 hasConcept C160756335 @default.
- W4366235785 hasConcept C171250308 @default.
- W4366235785 hasConcept C178790620 @default.
- W4366235785 hasConcept C181199279 @default.
- W4366235785 hasConcept C185592680 @default.
- W4366235785 hasConcept C18903297 @default.
- W4366235785 hasConcept C192562407 @default.
- W4366235785 hasConcept C21951064 @default.