Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366235791> ?p ?o ?g. }
- W4366235791 abstract "Data on drug-induced liver injury (DILI) caused by newer antiseizure medications (ASMs) in the elderly are scarce and mainly come from literature case reports. We analyzed Individual Case Safety Reports (ICSRs) of DILI in elderly patients treated with newer ASMs reported to VigiBase.Empirica™ Signal software was used to retrieve ICSRs reported to VigiBase up to 31 December 2021 and to calculate Empirical Bayesian Geometric Mean and corresponding 90% confidence intervals (EB05, EB95) for each drug-event pair. EB05 > 2, N > 0 was considered a signal. Analysis by age subgroups and gender was performed to assess the influence of these factors on ICSR characteristics and identified signals.There were 1399 ICSRs reporting 1947 events of hepatotoxicity. 56.97% of the reports were reported in females, 67.05% were serious, and 3.36% resulted in death. For one or more events of hepatotoxicity, signals were detected for lamotrigine, levetiracetam, oxcarbazepine, topiramate, and zonisamide. Age- and gender-biased reporting frequency was identified for topiramate-induced hyperammonemia, with disproportionally higher reporting frequency in ≥75-year-old male patients.The results of our study indicate differences among newer ASMs in their potential to cause DILI in the elderly. Further studies are needed to confirm the associations identified in this study." @default.
- W4366235791 created "2023-04-20" @default.
- W4366235791 creator A5005507886 @default.
- W4366235791 creator A5011117496 @default.
- W4366235791 creator A5053212155 @default.
- W4366235791 creator A5078793787 @default.
- W4366235791 date "2023-04-18" @default.
- W4366235791 modified "2023-10-16" @default.
- W4366235791 title "Drug-induced liver injury associated with the use of newer antiseizure medications in the elderly: an analysis of data from VigiBase" @default.
- W4366235791 cites W141640342 @default.
- W4366235791 cites W1481636658 @default.
- W4366235791 cites W1602028490 @default.
- W4366235791 cites W1962499748 @default.
- W4366235791 cites W1966268750 @default.
- W4366235791 cites W1975440270 @default.
- W4366235791 cites W1976522585 @default.
- W4366235791 cites W1979893692 @default.
- W4366235791 cites W1981809734 @default.
- W4366235791 cites W1986005428 @default.
- W4366235791 cites W1990506447 @default.
- W4366235791 cites W1995546772 @default.
- W4366235791 cites W1997435071 @default.
- W4366235791 cites W1998416434 @default.
- W4366235791 cites W2009890917 @default.
- W4366235791 cites W2020538649 @default.
- W4366235791 cites W2021326626 @default.
- W4366235791 cites W2026969166 @default.
- W4366235791 cites W2030920368 @default.
- W4366235791 cites W2057657462 @default.
- W4366235791 cites W2067583395 @default.
- W4366235791 cites W2073651893 @default.
- W4366235791 cites W2075352120 @default.
- W4366235791 cites W2078784493 @default.
- W4366235791 cites W2086049425 @default.
- W4366235791 cites W2107118502 @default.
- W4366235791 cites W2114705698 @default.
- W4366235791 cites W2123089829 @default.
- W4366235791 cites W2135996962 @default.
- W4366235791 cites W2136734328 @default.
- W4366235791 cites W2147845824 @default.
- W4366235791 cites W2154914124 @default.
- W4366235791 cites W2213220766 @default.
- W4366235791 cites W2259486064 @default.
- W4366235791 cites W2589613332 @default.
- W4366235791 cites W2611585213 @default.
- W4366235791 cites W2760412699 @default.
- W4366235791 cites W2767675234 @default.
- W4366235791 cites W2950024036 @default.
- W4366235791 cites W2960756630 @default.
- W4366235791 cites W2981369305 @default.
- W4366235791 cites W3039237517 @default.
- W4366235791 cites W3039914560 @default.
- W4366235791 cites W3070000681 @default.
- W4366235791 cites W3098923136 @default.
- W4366235791 cites W3126995511 @default.
- W4366235791 cites W3127199222 @default.
- W4366235791 cites W3133339510 @default.
- W4366235791 cites W3134387711 @default.
- W4366235791 cites W3172781743 @default.
- W4366235791 cites W4200061322 @default.
- W4366235791 cites W4221044684 @default.
- W4366235791 doi "https://doi.org/10.1080/17425255.2023.2203859" @default.
- W4366235791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37071502" @default.
- W4366235791 hasPublicationYear "2023" @default.
- W4366235791 type Work @default.
- W4366235791 citedByCount "0" @default.
- W4366235791 crossrefType "journal-article" @default.
- W4366235791 hasAuthorship W4366235791A5005507886 @default.
- W4366235791 hasAuthorship W4366235791A5011117496 @default.
- W4366235791 hasAuthorship W4366235791A5053212155 @default.
- W4366235791 hasAuthorship W4366235791A5078793787 @default.
- W4366235791 hasConcept C118552586 @default.
- W4366235791 hasConcept C126322002 @default.
- W4366235791 hasConcept C2777332695 @default.
- W4366235791 hasConcept C2777683783 @default.
- W4366235791 hasConcept C2778186239 @default.
- W4366235791 hasConcept C2778802184 @default.
- W4366235791 hasConcept C2779253243 @default.
- W4366235791 hasConcept C2780035454 @default.
- W4366235791 hasConcept C2781176495 @default.
- W4366235791 hasConcept C57658597 @default.
- W4366235791 hasConcept C71924100 @default.
- W4366235791 hasConcept C98274493 @default.
- W4366235791 hasConceptScore W4366235791C118552586 @default.
- W4366235791 hasConceptScore W4366235791C126322002 @default.
- W4366235791 hasConceptScore W4366235791C2777332695 @default.
- W4366235791 hasConceptScore W4366235791C2777683783 @default.
- W4366235791 hasConceptScore W4366235791C2778186239 @default.
- W4366235791 hasConceptScore W4366235791C2778802184 @default.
- W4366235791 hasConceptScore W4366235791C2779253243 @default.
- W4366235791 hasConceptScore W4366235791C2780035454 @default.
- W4366235791 hasConceptScore W4366235791C2781176495 @default.
- W4366235791 hasConceptScore W4366235791C57658597 @default.
- W4366235791 hasConceptScore W4366235791C71924100 @default.
- W4366235791 hasConceptScore W4366235791C98274493 @default.
- W4366235791 hasLocation W43662357911 @default.
- W4366235791 hasLocation W43662357912 @default.
- W4366235791 hasOpenAccess W4366235791 @default.
- W4366235791 hasPrimaryLocation W43662357911 @default.
- W4366235791 hasRelatedWork W1990192129 @default.