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- W4366235963 abstract "The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular factors through various mechanisms. Some of these factors are required for L1 amplification, while others either suppress or enhance specific steps during L1 propagation. Previously, TRIM28 has been identified to suppress transposable elements, including L1 expression via its canonical role in chromatin remodeling. Here, we report that TRIM28 through its B box domain increases L1 retrotransposition and facilitates shorter cDNA and L1 insert generation in cultured cells. Consistent with the latter, we observe that tumor specific L1 inserts are shorter in endometrial, ovarian, and prostate tumors with higher TRIM28 mRNA expression than in those with lower TRIM28 expression. We determine that three amino acids in the B box domain that are involved in TRIM28 multimerization are critical for its effect on both L1 retrotransposition and cDNA synthesis. We provide evidence that B boxes from the other two members in the Class VI TRIM proteins, TRIM24 and TRIM33, also increase L1 retrotransposition. Our findings could lead to a better understanding of the host/L1 evolutionary arms race in the germline and their interplay during tumorigenesis." @default.
- W4366235963 created "2023-04-20" @default.
- W4366235963 creator A5011001718 @default.
- W4366235963 creator A5025139807 @default.
- W4366235963 creator A5034751232 @default.
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- W4366235963 creator A5046961233 @default.
- W4366235963 creator A5079135989 @default.
- W4366235963 creator A5089103469 @default.
- W4366235963 creator A5089449964 @default.
- W4366235963 date "2023-04-18" @default.
- W4366235963 modified "2023-09-26" @default.
- W4366235963 title "A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis" @default.
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