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• W4366236126 abstract "Abstract Melanoma is originated from the malignant transformation of the melanocytes and is characterized by a high rate of invasion, the more serious stage compromising deeper layers of the skin and eventually leading to the metastasis. A high mortality due to melanoma lesion persists because most of melanoma lesions are detected in advanced stages, which decreases the chances of survival. The identification of the principal mechanics implicated in the development and progression of melanoma is essential to devise new early diagnosis strategies. Cell mechanics is related with a lot of cellular functions and processes, for instance motility, differentiation, migration and invasion. In particular, the elastic modulus (Young's modulus) is a very explored parameter to describe the cell mechanical properties; most cancer cells reported in the literature smaller elasticity modulus. In this work, we show that the elastic modulus of melanoma cells lacking galectin‐3 is significantly lower than those of melanoma cells expressing galectin‐3. More interestingly, the gradient of elastic modulus in cells from the nuclear region towards the cell periphery is more pronounced in shGal3 cells. Research Highlights AFM imaging and force spectroscopy were used to investigate the morphology and elasticity properties of healthy HaCaT cells and melanoma cells WM1366, with (shSCR) and without (shGal3) expression of galectin‐3. It is shown the effect of galectin‐3 protein on the elastic properties of cells: the cells without expression of galectin‐3 presents lower elastic modulus. By the results, we suggest here that galectin‐3 could be used as an effective biomarker of malignancy in both melanoma diagnostic and prognosis." @default.
• W4366236126 created "2023-04-20" @default.
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• W4366236126 date "2023-04-18" @default.
• W4366236126 modified "2023-10-14" @default.
• W4366236126 title "Role of galectin‐3 in the elastic response of radial growth phase melanoma cancer cells" @default.
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• W4366236126 doi "https://doi.org/10.1002/jemt.24328" @default.
• W4366236126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070727" @default.
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