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- W4366236441 abstract "The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation by macroautophagy. Here, we show that upon exposing Arabidopsis plants to intense light, NBR1 associates with photodamaged chloroplasts independently of ATG7, a core component of the canonical autophagy machinery. NBR1 coats both the surface and interior of chloroplasts, which is then followed by direct engulfment of the organelles into the central vacuole via a microautophagy-type process. The relocalization of NBR1 into chloroplasts does not require the chloroplast translocon complexes embedded in the envelope but is instead greatly enhanced by removing the self-oligomerization mPB1 domain of NBR1. The delivery of NBR1-decorated chloroplasts into vacuoles depends on the ubiquitin-binding UBA2 domain of NBR1 but is independent of the ubiquitin E3 ligases SP1 and PUB4, known to direct the ubiquitylation of chloroplast surface proteins. Compared to wild-type plants, nbr1 mutants have altered levels of a subset of chloroplast proteins and display abnormal chloroplast density and sizes upon high light exposure. We postulate that, as photodamaged chloroplasts lose envelope integrity, cytosolic ligases reach the chloroplast interior to ubiquitylate thylakoid and stroma proteins which are then recognized by NBR1 for autophagic clearance. This study uncovers a new function of NBR1 in the degradation of damaged chloroplasts by microautophagy." @default.
- W4366236441 created "2023-04-20" @default.
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- W4366236441 date "2023-04-18" @default.
- W4366236441 modified "2023-10-16" @default.
- W4366236441 title "The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts" @default.
- W4366236441 cites W1526993239 @default.
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- W4366236441 cites W1986887325 @default.
- W4366236441 cites W2007455466 @default.
- W4366236441 cites W2021039359 @default.
- W4366236441 cites W2026465178 @default.
- W4366236441 cites W2026753135 @default.
- W4366236441 cites W2028652127 @default.
- W4366236441 cites W2042838204 @default.
- W4366236441 cites W2044794038 @default.
- W4366236441 cites W2048226330 @default.
- W4366236441 cites W2052821301 @default.
- W4366236441 cites W2072017326 @default.
- W4366236441 cites W2074161304 @default.
- W4366236441 cites W2096494569 @default.
- W4366236441 cites W2100605768 @default.
- W4366236441 cites W2107114877 @default.
- W4366236441 cites W2108937618 @default.
- W4366236441 cites W2109323673 @default.
- W4366236441 cites W2116122104 @default.
- W4366236441 cites W2118983234 @default.
- W4366236441 cites W2119399459 @default.
- W4366236441 cites W2120557852 @default.
- W4366236441 cites W2125123150 @default.
- W4366236441 cites W2126530026 @default.
- W4366236441 cites W2128196453 @default.
- W4366236441 cites W2132546101 @default.
- W4366236441 cites W2133540908 @default.
- W4366236441 cites W2135686999 @default.
- W4366236441 cites W2140211966 @default.
- W4366236441 cites W2146124002 @default.
- W4366236441 cites W2152389843 @default.
- W4366236441 cites W2158215557 @default.
- W4366236441 cites W2167279371 @default.
- W4366236441 cites W2171984357 @default.
- W4366236441 cites W2236302923 @default.
- W4366236441 cites W2402781931 @default.
- W4366236441 cites W2463195069 @default.
- W4366236441 cites W2514339884 @default.
- W4366236441 cites W2580107677 @default.
- W4366236441 cites W2590407045 @default.
- W4366236441 cites W2736527864 @default.
- W4366236441 cites W2769524157 @default.
- W4366236441 cites W2789812805 @default.
- W4366236441 cites W2792139654 @default.
- W4366236441 cites W2801020340 @default.
- W4366236441 cites W2808859224 @default.
- W4366236441 cites W2810303648 @default.
- W4366236441 cites W2887008176 @default.
- W4366236441 cites W2901922019 @default.
- W4366236441 cites W2913223477 @default.
- W4366236441 cites W2916496760 @default.
- W4366236441 cites W2964619400 @default.
- W4366236441 cites W2973168210 @default.
- W4366236441 cites W3002026331 @default.
- W4366236441 cites W3036811453 @default.
- W4366236441 cites W3038464134 @default.
- W4366236441 cites W3048352105 @default.
- W4366236441 cites W3088482808 @default.
- W4366236441 cites W3106806651 @default.
- W4366236441 cites W3111521801 @default.
- W4366236441 cites W3175581376 @default.
- W4366236441 cites W3186242347 @default.
- W4366236441 cites W3190830764 @default.
- W4366236441 cites W3197867551 @default.
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- W4366236441 cites W4223956372 @default.
- W4366236441 cites W4281979571 @default.
- W4366236441 cites W4295079181 @default.
- W4366236441 cites W4306702013 @default.
- W4366236441 cites W4309245374 @default.
- W4366236441 cites W4312114624 @default.
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- W4366236441 doi "https://doi.org/10.7554/elife.86030" @default.
- W4366236441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070813" @default.
- W4366236441 hasPublicationYear "2023" @default.
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