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- W4366236495 endingPage "945" @default.
- W4366236495 startingPage "935" @default.
- W4366236495 abstract "Introduction Although sodium-glucose cotransporter-2 (SGLT2) inhibitors have risen in popularity for managing heart failure (HF) and chronic kidney disease (CKD), little guidance is available for the management of patients with an overlap of HF and CKD.Areas covered Following a brief review of the cardiorenal effects of SGLT2 inhibitors, this narrative review focused on the published clinical evidence pertaining to the cardiovascular and renal efficacy of SGLT2 inhibitors in patients with HF and CKD, including both randomized controlled trials and real-world observational studies. Real-world considerations of using SGLT2 inhibitors in these patients were also reviewed.Expert opinion Although no randomized controlled trial has specifically studied the use of SGLT2 inhibitors in patients with HF and CKD, evidence from existing trials is largely sufficient to demonstrate that SGLT2 inhibitors are efficacious in these patients, in whom these agents should be initiated early to maximally slow declines in renal function. Further studies should focus on better guiding the timing of initiating SGLT2 inhibitors, improving these agents’ cost-effectiveness, and bettering equity of access to these agents. Further areas of study may include the prognostic implications of SGLT2 inhibitors-induced changes in biomarker levels (e.g. natriuretic peptides), and the potentials of SGLT1 inhibition." @default.
- W4366236495 created "2023-04-20" @default.
- W4366236495 creator A5042717021 @default.
- W4366236495 creator A5043075532 @default.
- W4366236495 creator A5067430999 @default.
- W4366236495 creator A5068566752 @default.
- W4366236495 creator A5076118566 @default.
- W4366236495 date "2023-04-19" @default.
- W4366236495 modified "2023-09-27" @default.
- W4366236495 title "Emerging sodium-glucose cotransporter-2 inhibitor therapies for managing heart failure in patients with chronic kidney disease" @default.
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