Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366236802> ?p ?o ?g. }
- W4366236802 abstract "Metformin has been suggested to have protective effects on the central nervous system, but the mechanism is unknown. The similarity between the effects of metformin and the inhibition of glycogen synthase kinase (GSK)-3β suggests that metformin may inhibit GSK-3β. In addition, zinc is an important element that inhibits GSK-3β by phosphorylation. In this study, we investigated whether the effects of metformin on neuroprotection and neuronal survival were mediated by zinc-dependent inhibition of GSK-3β in rats with glutamate-induced neurotoxicity. Forty adult male rats were divided into 5 groups: control, glutamate, metformin + glutamate, zinc deficiency + glutamate, and zinc deficiency + metformin + glutamate. Zinc deficiency was induced with a zinc-poor pellet. Metformin was orally administered for 35 days. D-glutamic acid was intraperitoneally administered on the 35th day. On the 38th day, neurodegeneration was examined histopathologically, and the effects on neuronal protection and survival were evaluated via intracellular S-100β immunohistochemical staining. The findings were examined in relation to nonphosphorylated (active) GSK-3β levels and oxidative stress parameters in brain tissue and blood. Neurodegeneration was increased (p < 0.05) in rats fed a zinc-deficient diet. Active GSK-3β levels were increased in groups with neurodegeneration (p < 0.01). Decreased neurodegeneration, increased neuronal survival (p < 0.01), decreased active GSK-3β (p < 0.01) levels and oxidative stress parameters, and increased antioxidant parameters were observed in groups treated with metformin (p < 0.01). Metformin had fewer protective effects on rats fed a zinc-deficient diet. Metformin may exert neuroprotective effects and increase S-100β-mediated neuronal survival by zinc-dependent inhibition of GSK-3β during glutamate neurotoxicity." @default.
- W4366236802 created "2023-04-20" @default.
- W4366236802 creator A5012355501 @default.
- W4366236802 creator A5024482637 @default.
- W4366236802 creator A5034868535 @default.
- W4366236802 creator A5043323177 @default.
- W4366236802 creator A5044503612 @default.
- W4366236802 creator A5053434602 @default.
- W4366236802 creator A5064705780 @default.
- W4366236802 creator A5065142053 @default.
- W4366236802 creator A5068658655 @default.
- W4366236802 creator A5074508334 @default.
- W4366236802 creator A5087487985 @default.
- W4366236802 date "2023-04-18" @default.
- W4366236802 modified "2023-10-17" @default.
- W4366236802 title "The Role of Glycogen Synthase Kinase-3β in the Zinc-Mediated Neuroprotective Effect of Metformin in Rats with Glutamate Neurotoxicity" @default.
- W4366236802 cites W1590457525 @default.
- W4366236802 cites W1600770312 @default.
- W4366236802 cites W1719096380 @default.
- W4366236802 cites W1908612571 @default.
- W4366236802 cites W191793640 @default.
- W4366236802 cites W1964597381 @default.
- W4366236802 cites W1966259059 @default.
- W4366236802 cites W1969074927 @default.
- W4366236802 cites W1972317764 @default.
- W4366236802 cites W1972942987 @default.
- W4366236802 cites W1972986619 @default.
- W4366236802 cites W1974773445 @default.
- W4366236802 cites W1984407262 @default.
- W4366236802 cites W1988881753 @default.
- W4366236802 cites W1990527253 @default.
- W4366236802 cites W1994169350 @default.
- W4366236802 cites W1996291023 @default.
- W4366236802 cites W2006928461 @default.
- W4366236802 cites W2012868552 @default.
- W4366236802 cites W2017326328 @default.
- W4366236802 cites W2027044540 @default.
- W4366236802 cites W2030956146 @default.
- W4366236802 cites W2034357089 @default.
- W4366236802 cites W2034753731 @default.
- W4366236802 cites W2037619920 @default.
- W4366236802 cites W2038524016 @default.
- W4366236802 cites W2039426226 @default.
- W4366236802 cites W2042360443 @default.
- W4366236802 cites W2046503553 @default.
- W4366236802 cites W2046983229 @default.
- W4366236802 cites W2061333433 @default.
- W4366236802 cites W2076610425 @default.
- W4366236802 cites W2077852011 @default.
- W4366236802 cites W2087983133 @default.
- W4366236802 cites W2088477098 @default.
- W4366236802 cites W2091532682 @default.
- W4366236802 cites W2092262854 @default.
- W4366236802 cites W2093904239 @default.
- W4366236802 cites W2098091877 @default.
- W4366236802 cites W2101800953 @default.
- W4366236802 cites W2103676852 @default.
- W4366236802 cites W2136149884 @default.
- W4366236802 cites W2139191784 @default.
- W4366236802 cites W2141058716 @default.
- W4366236802 cites W2159305277 @default.
- W4366236802 cites W2162184782 @default.
- W4366236802 cites W2163768568 @default.
- W4366236802 cites W2232519133 @default.
- W4366236802 cites W2258420810 @default.
- W4366236802 cites W2265863784 @default.
- W4366236802 cites W2556339484 @default.
- W4366236802 cites W2596164815 @default.
- W4366236802 cites W2747084217 @default.
- W4366236802 doi "https://doi.org/10.1007/s12011-023-03667-3" @default.
- W4366236802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37071257" @default.
- W4366236802 hasPublicationYear "2023" @default.
- W4366236802 type Work @default.
- W4366236802 citedByCount "1" @default.
- W4366236802 countsByYear W43662368022023 @default.
- W4366236802 crossrefType "journal-article" @default.
- W4366236802 hasAuthorship W4366236802A5012355501 @default.
- W4366236802 hasAuthorship W4366236802A5024482637 @default.
- W4366236802 hasAuthorship W4366236802A5034868535 @default.
- W4366236802 hasAuthorship W4366236802A5043323177 @default.
- W4366236802 hasAuthorship W4366236802A5044503612 @default.
- W4366236802 hasAuthorship W4366236802A5053434602 @default.
- W4366236802 hasAuthorship W4366236802A5064705780 @default.
- W4366236802 hasAuthorship W4366236802A5065142053 @default.
- W4366236802 hasAuthorship W4366236802A5068658655 @default.
- W4366236802 hasAuthorship W4366236802A5074508334 @default.
- W4366236802 hasAuthorship W4366236802A5087487985 @default.
- W4366236802 hasBestOaLocation W43662368022 @default.
- W4366236802 hasConcept C126322002 @default.
- W4366236802 hasConcept C134018914 @default.
- W4366236802 hasConcept C170493617 @default.
- W4366236802 hasConcept C182996813 @default.
- W4366236802 hasConcept C184235292 @default.
- W4366236802 hasConcept C185592680 @default.
- W4366236802 hasConcept C192118531 @default.
- W4366236802 hasConcept C25498285 @default.
- W4366236802 hasConcept C2776151105 @default.
- W4366236802 hasConcept C2776925932 @default.
- W4366236802 hasConcept C2777499176 @default.
- W4366236802 hasConcept C2778004101 @default.