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• W4366236996 abstract "Abstract Objective To examine internal organ tissues and placentas of stillbirths for various pathogens. Design Prospective, observational study. Settings Three study hospitals in India and a large maternity hospital in Pakistan. Population Stillborn infants delivered in a study hospital. Methods A prospective observational study. Main outcome measures Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths. Results Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%). Conclusions In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain." @default.
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• W4366236996 date "2023-04-17" @default.
• W4366236996 modified "2023-10-14" @default.
• W4366236996 title "Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational <scp>PURPOSe</scp> study" @default.
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• W4366236996 doi "https://doi.org/10.1111/1471-0528.17479" @default.
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